Using advanced MRI to study brain metabolism in traumatic brain injury
Utility of Hyperpolarized 13C-Pyruvate Metabolic Magnetic Resonance Imaging in the Diagnosis of Early Cerebral Metabolic Crisis After Traumatic Brain Injury
This study is testing a new type of MRI to see how brain metabolism changes in people with traumatic brain injury compared to healthy individuals and those with a different brain condition.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT06103201 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the safety and feasibility of hyperpolarized metabolic MRI to investigate early changes in brain metabolism in patients with suspected non-penetrating traumatic brain injury (TBI). It will compare MRI-derived metrics from TBI patients to those from healthy subjects and patients with subarachnoid hemorrhage (SAH) to enhance diagnostic capabilities. The study will involve up to 15 participants, including 5 with TBI, 5 with SAH, and 5 healthy volunteers, all undergoing hyperpolarized 13C-pyruvate MRI scans at the University of Maryland, Baltimore.
Who should consider this trial
Good fit: Ideal candidates include individuals with a history of acute head injury and suspected non-penetrating TBI.
Not a fit: Patients who cannot undergo MRI scans or have severe reactions to contrast agents may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved diagnostic methods for traumatic brain injury.
How similar studies have performed: While the use of hyperpolarized MRI is a novel approach, similar studies have shown promise in assessing metabolic changes in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * History of acute head injury with or suspected non-penetrating acute TBI * Suitable to undergo contrast-enhanced MRI * Negative serum pregnancy test Exclusion Criteria: * Inability to undergo MRI scan * Inability to receive IV MRI contrast agents secondary to severe reaction or renal insufficiency * Positive pregnancy test
Where this trial is running
Baltimore, Maryland
- University of Maryland Baltimore — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Dirk Mayer, Dr. rer. nat. — University of Maryland, Baltimore
- Study coordinator: Rosy Linda Njonkou Tchoquessi
- Email: rnjonkou@som.umaryland.edu
- Phone: 410-706-0943
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.