Using advanced MRI to study brain metabolism in traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the safety and feasibility of hyperpolarized metabolic MRI to investigate early changes in brain metabolism in patients with suspected non-penetrating traumatic brain injury (TBI). It will compare MRI-derived metrics from TBI patients to those from healthy subjects and patients with subarachnoid hemorrhage (SAH) to enhance diagnostic capabilities. The study will involve up to 15 participants, including 5 with TBI, 5 with SAH, and 5 healthy volunteers, all undergoing hyperpolarized 13C-pyruvate MRI scans at the University of Maryland, Baltimore.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* History of acute head injury with or suspected non-penetrating acute TBI
* Suitable to undergo contrast-enhanced MRI
* Negative serum pregnancy test

Exclusion Criteria:

* Inability to undergo MRI scan
* Inability to receive IV MRI contrast agents secondary to severe reaction or renal insufficiency
* Positive pregnancy test

Where it's running

• University of Maryland Baltimore
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Dirk Mayer, Dr. rer. nat. — University of Maryland, Baltimore
• Study coordinator: Rosy Linda Njonkou Tchoquessi
• Email: rnjonkou@som.umaryland.edu
• Phone: 410-706-0943

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.