Preventing frailty in older adults with multiple health issues
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention Through Identification and Deep Phenotyping Methods in Healthy Aging and High-burden Disease Cohorts.
This study is trying to see how muscle health affects frailty in older adults with multiple health issues to improve their rehabilitation and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Tan Tock Seng Hospital Academic / other |
| Locations | 1 site (Singapore, Singapore) |
| Trial ID | NCT06073106 on ClinicalTrials.gov |
What this trial studies
This observational study aims to address frailty in older adults by examining the roles of osteosarcopaenia and multimorbidity. Investigators will create a common dataset to identify phenotypes and stratify risks associated with frailty in at-risk populations. The study will utilize early muscle ultrasound to assess muscle health and its correlation with rehabilitation outcomes. By developing a unified data platform, the study seeks to enhance screening and treatment strategies for frailty during rehabilitation.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling individuals aged 50 and older of Asian ethnicity with a first diagnosis of stroke, traumatic brain injury, knee osteoarthritis, or breast cancer.
Not a fit: Patients residing in nursing homes or those with severe impairments affecting their ability to understand tasks may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention strategies for frailty in older adults, enhancing their quality of life and reducing healthcare burdens.
How similar studies have performed: While the approach of targeting frailty through multimorbidity and osteosarcopaenia is gaining attention, this specific methodology is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 50y 2. Asian ethnicity 3. First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer) 4. Living in community 5. Able to understand 1 step simple commands 6. For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission 7. For outpatients: (i) \>6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking. Exclusion Criteria: 1. Nursing home or dormitory resident 2. Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass) 3. Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia, 4. Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium 5. Anticipated life expectancy \< 1 year 6. Presence of tracheostomy, ventilator, renal dialysis, end-organ failure 7. Patients with disorders of consciousness. 8. Pregnant or lactating participants For Knee Osteoarthritis patients only: 9. Alternative diagnosis to knee OA e.g. Referred pain from hip or spine. 10. Other forms of knee arthritis eg. Inflammatory, post traumatic 11. Previous knee arthroplasty
Where this trial is running
Singapore, Singapore
- Tan Tock Seng Hospital — Singapore, Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Karen Chua — Tan Tock Seng Hospital
- Study coordinator: Low Ai Mei Jaclyn
- Email: Jaclyn_AM_LOW@ttsh.com.sg
- Phone: 68894580
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.