Preventing frailty in older adults with multiple health issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to address frailty in older adults by examining the roles of osteosarcopaenia and multimorbidity. Investigators will create a common dataset to identify phenotypes and stratify risks associated with frailty in at-risk populations. The study will utilize early muscle ultrasound to assess muscle health and its correlation with rehabilitation outcomes. By developing a unified data platform, the study seeks to enhance screening and treatment strategies for frailty during rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 50y
2. Asian ethnicity
3. First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)
4. Living in community
5. Able to understand 1 step simple commands
6. For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission
7. For outpatients: (i) \>6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking.

Exclusion Criteria:

1. Nursing home or dormitory resident
2. Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)
3. Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,
4. Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium
5. Anticipated life expectancy \< 1 year
6. Presence of tracheostomy, ventilator, renal dialysis, end-organ failure
7. Patients with disorders of consciousness.
8. Pregnant or lactating participants

   For Knee Osteoarthritis patients only:
9. Alternative diagnosis to knee OA e.g. Referred pain from hip or spine.
10. Other forms of knee arthritis eg. Inflammatory, post traumatic
11. Previous knee arthroplasty

Where it's running

• Tan Tock Seng Hospital
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Karen Chua — Tan Tock Seng Hospital
• Study coordinator: Low Ai Mei Jaclyn
• Email: Jaclyn_AM_LOW@ttsh.com.sg
• Phone: 68894580

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.