Metabolomic profiling to find blood markers for severe traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that compares blood metabolite levels between adults with clinically defined severe TBI and orthopedic or multitrauma patients without brain injury. Researchers will use metabolomic techniques to measure small molecules (under 500 Da) in systemic circulation to look for signatures related to energy failure and blood–brain barrier dysfunction after TBI. The goal is to identify metabolites that correlate with injury severity or prognosis rather than to test a therapy. Enrollment is for adults aged 18–65 and the work is conducted at a single tertiary hospital in Ankara, Turkey.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 18-65
* Patients diagnosed with severe TBI clinically or according to National Institute for Health and Care Excellence (NICE) criteria (including post-traumatic imaging)
* Patients with non-TBI orthopedic or multitrauma

Exclusion Criteria:

* Presence of brain pathology in the pre-trauma period
* Patient with chronic subdural hematoma

Where it's running

• Aksaray University
  Aksaray, Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Hazal Ekin AYTUĞ, Consultant anesthesiologist
• Email: drekinguran@gmail.com
• Phone: +905078448449

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.