Using egg yolk powder to treat severe traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Salovum, an egg yolk powder enriched with antisecretory factor, in addition to standard care for patients with severe traumatic brain injury. Participants will be randomly assigned to receive either Salovum or a placebo egg yolk powder, and various parameters such as intracranial pressure, brain oxygen levels, and inflammatory markers will be monitored. The goal is to assess whether Salovum can reduce cerebral edema and improve patient outcomes compared to standard treatment alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Severe traumatic brain injury, Glasgow Outcome Scale (GCS) \<9 at admission to NICU.

Clinical indication for insertion of intracranial pressure monitor, intracerebral oxygen pressure monitor and microdialysis catheter.

Consultation with relatives or consent from guardians.

Exclusion Criteria:

Known egg yolk allergy.

Unilateral or bilateral fixed and dilated pupil after initial operative intervention.

Where it's running

• Skane University Hopsital
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Peter Siesjö, MD, PhD — Skane University Hospital
• Study coordinator: Peter Siesjö, MD, PhD
• Email: peter.siesjo@med.lu.se
• Phone: +4646171274

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.