Collecting and analyzing clinical and molecular data in patients with traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to improve the evaluation and prognosis prediction of patients with traumatic brain injury (TBI) by collecting and analyzing clinical data alongside molecular biomarkers obtained through single-cell sequencing. Eligible patients will undergo surgical treatment, during which brain tissue will be preserved for further analysis. The study will utilize high-throughput sequencing and bioinformatics to identify significant biomarkers and compare them with existing evaluation methods. The goal is to develop a regression model that correlates neurological status with various clinical factors, enhancing the accuracy of patient outcome predictions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* CT/MRI confirmed TBI;
* The time from onset to the emergency room (ER ) within 12h;
* The systolic pressure (SBP) ≥ 90 mmHg;
* Patients willing to participate in this study with signed informed consent.

Exclusion Criteria:

* Patients who are not suitable for surgery (GCS score 3 points, dilated and fixed bilateral pupils, pregnant women, etc.);
* Pre-injury life expectancy ≤ 1 year (malignant tumor);
* Previous history of acute myocardial infarction, abnormal immune function, and blood-related diseases;
* without informed consent.

Where it's running

• Shanghai 6th People's Hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yang Yang, MD, PhD
• Email: yang.cne.yang@gmail.com
• Phone: 18210391762

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.