Understanding brain activity after severe traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates brain activity using electrodes placed on the brain to record and analyze cortical spreading depolarizations (CSDs) following severe traumatic brain injury (TBI) that requires neurosurgical intervention. The aim is to enhance understanding of CSDs as a mechanism of secondary injury, which can worsen outcomes after TBI. By identifying the factors that influence CSD initiation and frequency, the study seeks to inform potential therapeutic strategies to mitigate secondary brain injury. The research is observational and focuses on patients undergoing craniectomy or craniotomy for acute TBI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient recommended to undergo craniectomy or craniotomy for the treatment of acute TBI

Exclusion Criteria:

* Wound determined to be contaminated
* Decompression is performed only in the posterior fossa
* Known systemic infection
* Pregnancy

Where it's running

• Hennepn Healthcare
  Minneapolis, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Samuel W Cramer, MD, PhD — University of Minnesota Neurosurgery Department; Division of Neurosurgery, Department of Surgery, Hennepin County Medical Center
• Study coordinator: Samuel W Cramer, MD, PhD
• Email: rnl@umn.edu
• Phone: 612-624-6666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.