Condition

Post Traumatic Stress Disorder clinical trials and research

• 94Clinical trials
• 26NIH research projects
• 16Countries

Newest Post Traumatic Stress Disorder clinical trials

All recruiting trials (94)

• Anger, Social Thinking, and PTSD in French Veterans

  This study tests whether PTSD in former French military personnel is linked to higher anger through changes in social thinking abilities.

  Recruiting Direction Centrale du Service de Santé des Armées · Draguignan · NCT07851090

• TSND-201 treatment for PTSD in adults

  This study tests two doses of TSND-201 or placebo to see if it helps adults with PTSD.

  Recruiting at 9 sites Phase 3 Transcend Therapeutics · Denver, Colorado and 8 other locations · NCT07836647

• Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD

  This study tests whether benefits from HBOT persist over time for veterans with brain injury or related conditions.

  Recruiting Phase 2 Summit Hyperbarics and Wellness · Boise, Idaho · NCT07732374

• SEE FAR CBT for Adults With PTSD

  This 12-week, one-on-one SEE FAR CBT program tests a trauma-focused therapy to see if PTSD symptoms improve in adults 18 and older.

  Recruiting Community Stress Prevention Center · Kiryat Shmona · NCT07720674

• Brief SEE FAR CBT: a short, focused therapy for adults with PTSD

  A 6-session Brief SEE FAR CBT treatment is tested against usual dynamic psychotherapy for adults with PTSD to see if it reduces symptoms.

  Recruiting Community Stress Prevention Center · Sha'ar Hanegev · NCT07710573

• MDMA Therapy for PTSD in Veterans

  This phase 2 study tests a fixed 120 mg dose of MDMA, followed by a 60 mg supplemental dose, plus therapy, to see if it helps adults who are veterans with PTSD.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT07569159

• Predicting childbirth PTSD after unplanned cesarean using early postpartum screening

  This study tests whether brief postpartum questionnaires taken 24-48 hours after delivery can predict childbirth-related PTSD symptoms at 6 weeks in people who had an unplanned cesarean.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07561632

• Non-invasive vagus nerve stimulation (gammaCore) for PTSD

  This study will test whether the handheld gammaCore device, which delivers mild electrical stimulation to the vagus nerve through the neck, can help adults with PTSD reduce their symptoms.

  Recruiting Acacia Clinics · Sunnyvale, California · NCT07523685

• Beetroot juice to improve blood vessel health in women with PTSD

  This study will test whether drinking beetroot juice can improve blood vessel function in young women who have experienced trauma or have PTSD.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07485231

• TSND-201 treatment for adults with PTSD (EMPOWER-1)

  This test tries to see if weekly doses of TSND-201 reduce PTSD symptoms in adults who have had PTSD for at least six months and tried prior treatments.

  Recruiting at 37 sites Phase 3 Transcend Therapeutics · Phoenix, Arizona and 36 other locations · NCT07456696

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• Impact on quality of life after an intensive care unit stay

  This project will see if adults who spend more than 48 hours in intensive care develop post‑traumatic stress that affects their quality of life.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07339891

• Building Ukraine's strength in PTSD treatment

  This project will try the Reconsolidation of Traumatic Memories (RTM) protocol alongside standard PTSD treatments to see if it reduces symptoms in adults with PTSD living in Ukraine.

  Recruiting at 2 sites University of Luxembourg · Kyiv and 1 other locations · NCT07318181

• MDMA with intensive prolonged exposure therapy for PTSD

  This trial will test whether adding a single dose of MDMA to a two-week course of intensive prolonged exposure therapy helps adults with PTSD reduce their symptoms more than therapy with a placebo.

  Recruiting Phase 2 Emory University · Atlanta, Georgia · NCT07288151

• Being Safe, Healthy, and Positively Empowered (BSHAPE) for foreign-born women

  This project will test a trauma-informed digital program (BSHAPE) to see if it improves safety, mental health, and related health risks for foreign-born immigrant women with histories of violence and PTSD or depression.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07227337

• Recovering sleep after a car crash

  This pilot will test whether four remote sessions of brief behavioral treatment for insomnia (BBTI) help people recently seen in the ER for a motor vehicle crash who are at high risk for PTSD and depression.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07196332

• MDMA-assisted therapy for veterans with PTSD and alcohol use disorder

  This study tests MDMA-assisted therapy versus a low-dose MDMA placebo with psychotherapy to see if it helps veterans who have PTSD and problem drinking.

  Recruiting at 2 sites Phase 2/3 VA Office of Research and Development · West Haven, Connecticut and 1 other locations · NCT07118839

• Mindfulness-based Psilocybin Therapy for PTSD

  This study tests whether psilocybin given with mindfulness-based therapy helps PTSD symptoms in adults who also have depression.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT07104916

• IV allopregnanolone to improve extinction retention and block reconsolidation in PTSD.

  This study will test whether a single IV dose of allopregnanolone helps adults with chronic PTSD better retain extinction learning or block reconsolidation of traumatic responses.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07079761

• Treatment to improve heart rate variability for long-term concussion symptoms

  This trial tests whether a non-invasive heart rate variability biofeedback program can reduce long-term post-concussion symptoms in adults with a history of mild TBI, including veterans and service members.

  Recruiting Phase 2/3 Virginia Commonwealth University · Richmond, Virginia · NCT07071350

• NightWare use for cardiovascular health in women with PTSD-related nightmares

  This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07021014

• Walk With Me for Perinatal Grief

  A mobile app-based program (Along With Me) with or without a Peer Guide is tested to see if it lowers posttraumatic stress and suicidal thoughts in bereaved parents after pregnancy or early infant loss.

  Recruiting Oregon Research Behavioral Intervention Strategies, Inc. · Eugene, Oregon and 1 other locations · NCT07011940

• Partner-assisted therapy for PTSD in veterans

  This study tests if involving partners in therapy can help veterans with PTSD feel better and improve their treatment results.

  Recruiting United States Department of Defense · Phoenix, Arizona and 3 other locations · NCT06990191

• Program to restore resilience and reduce PTSD after military sexual trauma or intimate partner violence with brain injury

  This trial tests whether adding a web-based emotion regulation program to exposure therapy helps female Veterans with military sexual trauma or intimate partner violence and a history of brain injury reduce PTSD symptoms.

  Recruiting Icahn School of Medicine at Mount Sinai · Houston, Texas · NCT06988787

• Improving PTSD therapy outcomes for veterans

  This study is testing whether two different ways of helping veterans with PTSD stick to their therapy can improve their treatment results.

  Recruiting at 4 sites United States Department of Defense · Phoenix, Arizona and 3 other locations · NCT06957067

• Stepped care approach for PTSD

  This program tests a stepped care pathway that starts everyone on a web-based skills program and adds coaching or brief clinician treatments as needed for adults with PTSD.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT06947538

• BXCL501 given shortly after a car crash to reduce acute stress and later PTSD symptoms

  This will test whether a short course of BXCL501 sublingual film given in the emergency department after a motor vehicle collision can reduce acute stress symptoms and lower the chance of developing PTSD in high‑risk adults.

  Recruiting at 2 sites Phase 2 University of North Carolina, Chapel Hill · Jacksonville, Florida and 2 other locations · NCT06943404

• Psilocybin-assisted therapy for PTSD after sexual assault

  This trial will test whether a single 25 mg oral dose of psilocybin combined with therapy helps cisgender women who have PTSD from a sexual assault.

  Recruiting Phase 2 Sunstone Medical · Rockville, Maryland · NCT06902974

• Short-term therapy for PTSD symptoms

  This study is testing a week-long therapy to see if it can help adults with PTSD feel better and reduce their symptoms.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT06826937

• Augmented reality-enhanced exposure therapy for PTSD in U.S. military personnel

  This tests whether adding augmented reality to standard exposure therapy helps U.S. military veterans and active-duty adults with PTSD.

  Recruiting Wayne State University · Charleston, South Carolina · NCT06740487

• Improving mental health for Venezuelan migrants in Peru

  This study is testing a new online therapy program to see if it can help Venezuelan migrants in Peru who are struggling with anxiety, depression, and PTSD.

  Recruiting Boston Medical Center · Lima · NCT06635486

• Rehabilitation for stroke patients using nature-based therapies

  This study tests if nature-based rehabilitation can help people who have recently had a stroke recover better than those who only do light physical activity.

  Recruiting Joint Authority for Päijät-Häme Social and Health Care · Lahti · NCT06633146

• Working memory training to improve fear extinction in veterans with PTSD

  This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06629064

• Support for trauma exposure victims

  This study tests a new online therapy for people dealing with post-traumatic stress symptoms after a traumatic event to see if it helps them feel better and is cost-effective.

  Recruiting at 29 sites Norwegian Center for Violence and Traumatic Stress Studies · Asker, Asker and 28 other locations · NCT06592677

• EEG‑guided propofol to induce dreaming as a therapy for PTSD

  This trial will test whether EEG‑guided propofol anesthesia that induces dreaming can reduce symptoms in adults with PTSD.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT06577636

• Rapid treatment for PTSD using brain stimulation

  This study is testing a quick brain stimulation treatment for people with PTSD to see if it can help reduce their symptoms in just one week.

  Recruiting Florida State University · Tallahassee, Florida · NCT06544408

• Mobile app training to help ICU survivors manage psychological distress

  This study is testing a mobile app that helps ICU survivors learn coping skills to see if it can reduce their feelings of anxiety, depression, and PTSD.

  Recruiting Duke University · Durham, North Carolina · NCT06538246

• Trauma-Focused Cognitive-Behavioral Therapy for PTSD Treatment

  This study is testing if a new online therapy for complex PTSD can help adults feel better compared to the usual treatment they receive.

  Recruiting at 5 sites University of Talca · Curicó, Maule Region and 4 other locations · NCT06516874

• Improving sleep for Veterans with traumatic brain injury, PTSD, and chronic pain

  We will try morning bright light therapy at home to improve sleep for Veterans who have TBI, PTSD, and chronic pain.

  Recruiting VA Office of Research and Development · Portland, Oregon · NCT06477796

• Using Silexan to treat Posttraumatic Stress Disorder

  This study is testing if Silexan, a treatment made from lavender oil, can help people with Posttraumatic Stress Disorder feel better compared to a placebo.

  Recruiting at 4 sites Phase 3 Deakin University · Carlton, Victoria and 3 other locations · NCT06412757

• Warrior CARE: Cannabis Behavioral Health

  This study tests whether different cannabis compounds (THC, CBD, or THC+CBD) or placebo can help veterans with PTSD and suicidal thoughts over 12 weeks.

  Recruiting Phase 1/2 Wayne State University · Detroit, Michigan · NCT06381180

• Imaging brain changes in PTSD and Alcohol Use Disorder

  This study is testing if brain imaging can help us understand how a specific marker is related to PTSD and Alcohol Use Disorder in people who have these conditions.

  Recruiting Yale University · New Haven, Connecticut · NCT06371404

• Exploring the link between sleep and emotions in teens with PTSD

  This study is testing if improving sleep quality can help teens with PTSD feel better emotionally and improve their mood during the day.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06341413

• Comparing telehealth and in-person therapy for youth with PTSD in Puerto Rico

  This study tests whether therapy for PTSD delivered online works as well as in-person therapy for young people in Puerto Rico who have experienced trauma.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06332209

• Using eTMS to treat PTSD in veterans and first responders

  This study is testing a new brain treatment called eTMS to see if it can help veterans and first responders with PTSD feel better.

  Recruiting Virginia Polytechnic Institute and State University · Roanoke, Virginia · NCT06294106

• Brief treatment for anxiety and PTSD in South Africa

  This study is testing a new, simple treatment for anxiety and PTSD in South Africa to see if it helps people feel better compared to regular care.

  Recruiting Massachusetts General Hospital · Cape Town · NCT06289621

• Cognitive training for anxiety, depression, and PTSD

  This study is testing a brain training program to see if it can help people with anxiety, depression, or PTSD think more clearly and feel better.

  Recruiting Phase 2/3 University of California, San Diego · San Diego, California · NCT06273527

• Very brief exposure to combat images for PTSD in veterans

  This study is testing a new way to help U.S. combat veterans with PTSD by briefly showing them combat images to see if it can reduce their fear without causing too much distress.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06218381

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Understanding psychotherapy changes in traumatized teenagers

  This study looks at how teenagers aged 12 to 18 with PTSD feel about their therapy experiences to see what helps them heal from trauma.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, IDF · NCT06138522

• Effects of psychotherapy on brain function in PTSD

  This study is testing whether trauma-focused therapy can change how the brain processes rewards in people with chronic PTSD to see if it helps them feel more positive emotions.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06096740

• Personalized brain stimulation for long-term symptoms after concussion

  This study will try personalized, noninvasive brain stimulation (TMS) to reduce dizziness, headaches, memory problems, and other lasting symptoms in adults aged 18–65 after a concussion.

  Recruiting Phase 2 University of California, Los Angeles · Westwood, Los Angeles, California · NCT06073886

• Home use of ketamine for chronic conditions

  This study is testing whether taking ketamine at home can help people with chronic pain, depression, or PTSD feel better and improve their symptoms.

  Recruiting at 2 sites RIVER Foundation · Bigfork, Montana and 1 other locations · NCT06070766

• Trauma therapy for patients with PTSD and psychotic disorders

  This study is testing if a specific trauma therapy can help people with both PTSD and psychotic disorders feel better over time.

  Recruiting Medicalschool Hamburg · Hamburg · NCT06048172

• MDMA-assisted therapy for PTSD and relationship improvement

  This study is testing whether therapy that includes MDMA can help couples with PTSD feel better and improve their relationship compared to regular therapy.

  Recruiting Phase 2 Remedy · Toronto, Ontario · NCT06044675

• Sensory Motor Arousal Regulation Treatment (SMART) for PTSD

  We will try a movement- and body-based therapy called SMART to help adults with PTSD.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06035809

• Understanding how alcohol affects decision-making in people with PTSD

  This study tests how drinking alcohol affects decision-making in adults with PTSD to see if it helps us understand their relationship with alcohol use and improve treatment options.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06002633

• Comparing intensive and standard treatment for PTSD in adults

  This study is testing if a new, more intense 5-day therapy for PTSD can help adults recover faster and better than the usual weekly sessions over 15 weeks.

  Recruiting Karolinska Institutet · Stockholm · NCT05934175

• Exploring how ketamine's effects on depression relate to AMPA receptors

  This study is testing if blocking certain brain receptors affects how well ketamine helps people with depression who haven't responded to other treatments.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT05915013

• Exploring cognitive biases in people bereaved by violent death

  This study is trying to understand how losing a loved one to violence affects people's thinking and feelings, to see if it can help identify early signs of PTSD and depression.

  Recruiting Hôpital le Vinatier · Bron · NCT05874362

• MDMA therapy for veterans with PTSD

  This study is testing whether MDMA therapy can help veterans with moderate to severe PTSD feel better compared to a low dose of d-amphetamine therapy.

  Recruiting Phase 2 VA Greater Los Angeles Healthcare System · Los Angeles, California and 1 other locations · NCT05790239

• How prolonged exposure therapy helps people with PTSD.

  This project will see if brain activity, bodily responses, and symptom reports change across 10 sessions of Prolonged Exposure and predict improvement in adults with PTSD.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05788302

• Examining how AMPA receptor blockade affects Ketamine's ability to reduce suicidal thoughts

  This study is testing if a medication called perampanel can improve the effects of Ketamine in reducing suicidal thoughts and depression in people with major depressive disorder, bipolar disorder, or PTSD.

  Recruiting Phase 2 Yale University · West Haven, Connecticut · NCT05786066

• Reducing PTSD symptoms in first responders and healthcare workers

  This study tests if a new talk therapy for PTSD can help first responders and healthcare workers feel better than the usual support they get.

  Recruiting at 10 sites University of Michigan · San Diego, California and 13 other locations · NCT05751473

• MDMA-assisted therapy for war-related PTSD — a hybrid individual and group approach

  This study tests whether a flexible-dose MDMA-assisted therapy can be safe and show preliminary benefit for people with war-related PTSD.

  Recruiting Phase 2 HaEmek Medical Center, Israel · Afula · NCT05732155

• Improving mental health in schools through mindfulness and therapy

  This study is testing a mindfulness program for teachers and a special therapy for kids in Puerto Rico to see if it helps them feel less stressed and recover from trauma.

  Recruiting Stanford University · Palo Alto, California and 2 other locations · NCT05701111

• Using brain imaging to improve treatment for PTSD with TMS

  This study is testing if brain scans can help improve a treatment called rTMS for people with PTSD by finding out how it affects their brain.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT05646732

• Virtual reality exercise program for women veterans

  This study is testing a new virtual reality exercise program to see if it can help women veterans improve their physical and mental health over eight weeks.

  Recruiting The University of Texas at Arlington · Arlington, Texas · NCT05563805

• Reducing fear memories to prevent PTSD

  This study is testing whether a new method using brain stimulation can help prevent PTSD by reducing fear memories right after a traumatic event.

  Recruiting at 2 sites Emory University · Atlanta, Georgia and 1 other locations · NCT05560113

• Multi-level school intervention for LGBTQ youth

  This study is testing a new program in high schools to see if it helps LGBTQ youth deal with bullying and improve their mental health and school environment.

  Recruiting Washington University School of Medicine · El Monte, California and 22 other locations · NCT05541406

• Evaluating CO2 Reactivity to Predict Response to Exposure Therapy for Anxiety Disorders

  This study is testing whether measuring how people react to CO2 can help predict if adults with anxiety disorders will benefit from exposure therapy.

  Recruiting at 2 sites University of Texas at Austin · Boston, Massachusetts and 1 other locations · NCT05467683

• Pimavanserin for treating insomnia in veterans with PTSD

  This study is testing if a medication called pimavanserin can help veterans with PTSD sleep better by comparing it to a placebo over eight weeks.

  Recruiting Phase 2 VA Office of Research and Development · Houston, Texas · NCT05441280

• Eye-tracking attentional therapy to reduce PTSD symptoms

  This trial tests whether adding eye-tracking to attention-control training can reduce PTSD symptoms in French-speaking adults with PTSD.

  Recruiting University Hospital, Lille · Lille · NCT05331534

• PAP treatment for veterans with PTSD and substance use disorder

  This study tests if using a breathing device for sleep apnea can help veterans with PTSD and substance use issues stick to their treatment and feel better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT05156112

• Using brain stimulation to enhance therapy for PTSD in veterans

  This study is testing whether combining brain stimulation with therapy can help veterans with PTSD feel better and cope with their symptoms.

  Recruiting VA Office of Research and Development · Temple, Texas · NCT05149534

• Enhancing memory through amygdala stimulation

  This study is testing if stimulating a part of the brain called the amygdala can help improve memory in people with epilepsy who are being monitored for seizures.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05065450

• Case management for women victims of violence

  This study is testing a new support program for women who have experienced violence to see if it helps them get better mental health care and reduces their risk of PTSD.

  Recruiting University Hospital, Lille · Amiens and 7 other locations · NCT04953273

• Understanding how PTSD patients learn to avoid fear triggers

  This study is testing how people with PTSD learn to avoid things that trigger their fear and how their brain reacts to this learning.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT04770584

• Using breathing techniques to prevent chronic PTSD after trauma

  This study is testing if breathing techniques can help people with acute stress disorder after a trauma avoid developing chronic PTSD.

  Recruiting Centre Hospitalier Universitaire de la Réunion · Saint-Paul · NCT04701723

• Helping healthcare workers cope with psychological distress from COVID-19

  This study is testing two different ways to help healthcare workers cope with stress and trauma from their experiences during the COVID-19 pandemic.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT04626050

• Improving therapeutic learning for PTSD in women

  This study is testing whether a medication that affects dopamine can help women with PTSD from physical or sexual assault feel less fear during therapy.

  Recruiting Phase 2 University of Wisconsin, Madison · Austin, Texas and 1 other locations · NCT04558112

• Using cannabidiol to treat PTSD and traumatic brain injury symptoms

  This study is testing if taking cannabidiol (CBD) can help people with PTSD, some of whom also have mild brain injuries, feel better compared to a placebo.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT04550377

• Culturally adapted brief PTSD program for people with severe mental illness in Botswana

  This pilot tests whether a three-week BREATHE program can help people in Botswana who have both severe mental illness and PTSD feel better and learn to manage symptoms.

  Recruiting University of Botswana · Lobatse · NCT04426448

• Therapeutic treatment for PTSD using Deep Brain Reorienting

  This study is testing a new treatment called Deep Brain Reorienting to see if it can help people with PTSD manage their symptoms better.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT04317820

• Creative arts program to help healthcare professionals with burnout

  This study is testing whether creative arts programs can help critical care healthcare professionals feel less burned out and improve their mental health.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04276922

• Combining rTMS and Cognitive Therapy for Combat-related PTSD

  This study is testing whether combining a brain treatment called rTMS with therapy can help veterans with combat-related PTSD feel better.

  Recruiting at 3 sites The University of Texas at Dallas · Tallahassee, Florida and 2 other locations · NCT03932773

• Combining brain stimulation with cognitive training for mild traumatic brain injury

  This study is testing whether combining brain stimulation with attention training can help people with mild traumatic brain injury and PTSD improve their focus and attention.

  Recruiting Northwestern University · Chicago, Illinois and 1 other locations · NCT03819608

• Using topiramate to treat alcohol use disorder and PTSD together

  This study is testing if the medication topiramate can help people who have both alcohol use disorder and PTSD feel better.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT03667846

• Using morning bright light to improve sleep in veterans

  This study is testing if morning bright light therapy can help improve sleep quality for veterans with traumatic brain injuries.

  Recruiting Portland VA Medical Center · Portand, Oregon · NCT03578003

• Evaluating retinal imaging for neurodegenerative diseases

  This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.

  Recruiting Duke University · Durham, North Carolina · NCT03233646

• Non-invasive nerve stimulation to improve sleep in PTSD and TBI patients

  This study is testing two types of nerve stimulation to see if they can help veterans with PTSD and mild brain injuries sleep better.

  Recruiting at 3 sites University of Florida · Gainesville, Florida and 2 other locations · NCT03170440

• Registry for improving mental health care in the Maritimes

  This study is trying to improve mental health care for people with depression in the Maritimes by creating a registry that helps track treatments and outcomes while involving those who have experienced these challenges.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT02443636

• Imaging cannabinoid receptors in the brain using PET scans

  This study is trying to see how many cannabinoid receptors are in the brains of healthy people and those with conditions like cannabis use disorders or PTSD using special brain scans.

  Recruiting Yale University · New Haven, Connecticut · NCT01730781

• Evaluating therapies for sympathetic overactivity in PTSD

  This study is testing if breathing exercises and a nerve stimulation device can help people with PTSD reduce their stress response and improve their heart health.

  Recruiting Emory University · Decatur, Georgia · NCT01627301

NIH-funded research (26)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pimavanserin for Sleep Problems in Veterans with PTSD

  This grant supports Dr. Melissa Jones to study a new medicine, pimavanserin, to help veterans with PTSD sleep better.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11591888

• A new sleep-help approach for Veterans with PTSD

  A new ACT-based insomnia treatment tailored for Veterans with PTSD aims to improve sleep and quality of life.

  NIH research Miami VA Health Care System · Miami, United States · NIH-11547958

• Novel digital therapeutic app to help adults with PTSD

  A new mobile app-based treatment for adults living with PTSD aims to provide an accessible, personalized therapy option.

  NIH research Oui Therapeutics, INC · New Haven, United States · NIH-11536935

• Light touches the brain: targeted ultrasound to help frontline workers with PTSD

  A single, MRI-guided low-intensity focused ultrasound session is being tested to gently modulate a brain circuit involved in PTSD for frontline healthcare workers who have PTSD symptoms.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11460267

• Methylphenidate for PTSD with cognitive symptoms in veterans

  A controlled trial tests whether methylphenidate helps veterans with PTSD and cognitive problems feel and think more clearly.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11335009

• Preventing awareness during paralysis in emergency ventilated patients and reducing PTSD

  This project will change emergency department medication defaults to cut back on a paralytic drug and see if that lowers the chance that adults put on ventilators wake up while paralyzed and later develop PTSD.

  NIH research Washington University · Saint Louis, United States · NIH-11325301

• Acceptance-based sleep program for Veterans with PTSD

  This program combines behavioral sleep techniques with Acceptance and Commitment Therapy to help Veterans with PTSD who have chronic insomnia.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11269164

• Sleep and emotions in teens with PTSD

  This project looks at whether brain sleep patterns relate to how teens with PTSD process emotions and feel day-to-day.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11248053

• Shared brain and behavior changes linking PTSD and alcohol problems

  This project uses animal models to look at brain and behavior changes that may underlie PTSD and alcohol use problems, aiming to guide new treatments for people with both conditions.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11238075

• Testing a medication to improve cognitive function and reduce PTSD symptoms in Veterans

  This study is looking at whether a medication called methylphenidate, often used for ADHD, can help improve thinking skills and reduce PTSD symptoms in Veterans, especially those who also have mild brain injuries. If you’re a Veteran dealing with these issues, you might be able to join and see if this medication works

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11204585

• CBT-based text messages to reduce PTSD symptoms and risky drinking

  Short, self-directed cognitive-behavioral text messages aim to help adults with PTSD symptoms who also drink heavily reduce symptoms and risky drinking.

  NIH research University of Washington · Seattle, United States · NIH-11162325

• Exploring the genetic factors behind post-traumatic stress disorder.

  This study is looking at how our genes might influence post-traumatic stress disorder (PTSD) by examining different types of genetic information, and it hopes to find new ways to understand and treat PTSD better for those who experience it.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11139732

• Creating a mobile app to help adults with PTSD

  This study is testing a new mobile app called OTX-601 that aims to help adults with post-traumatic stress disorder (PTSD) by making treatment easier and more personal, so you can manage your symptoms right from your phone.

  NIH research Oui Therapeutics, INC · New Haven, United States · NIH-11105937

• Investigating brain inflammation in PTSD and its link to Alzheimer's disease

  This study is looking at how inflammation in the brain might affect memory and anxiety in people with PTSD by examining brain tissue from those who had the condition, to see if there are changes that could also relate to Alzheimer's disease.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11105764

• Investigating awareness and PTSD in patients on mechanical ventilation in the emergency department

  This study is looking at how many patients on ventilators in the emergency department are aware of what's happening around them and how that might affect their mental health, especially in terms of PTSD, so we can find better ways to help them feel more comfortable and supported during their care.

  NIH research Washington University · Saint Louis, United States · NIH-11060876

• Investigating how sleep affects emotions in adolescents with PTSD

  This study is looking at how sleep affects emotions in teenagers aged 15-18 with PTSD, as well as those who have experienced trauma but don’t have PTSD, and those who are typically developing, to see how their sleep quality might influence how they feel and react to emotions.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11051261

• A new treatment for insomnia in veterans with PTSD

  This study is testing a new way to help veterans with PTSD who have trouble sleeping by combining helpful sleep habits with a special therapy called Acceptance and Commitment Therapy, to see if it can improve their sleep quality.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11019747

• Using Pimavanserin to improve sleep in veterans with PTSD

  This study is looking at how the medication Pimavanserin, usually used for Parkinson's disease, can help veterans with PTSD sleep better and feel less anxious, and it’s being led by Dr. Melissa Beth Jones.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-10975958

• Testing a medication to help Veterans with PTSD and recent strokes.

  This study is looking at whether a medication called methylphenidate can help Veterans who have both PTSD and have recently had a stroke feel better and function more easily in their daily lives.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-10975942

• Responsive brain stimulation for severe PTSD

  This project uses a small implanted device that senses fear-related brain activity and delivers brief electrical pulses to help veterans with severe, treatment-resistant PTSD.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10911268

• Using Stellate Ganglion Block to treat PTSD in veterans

  This study is looking at whether a special treatment called Stellate Ganglion Block can help veterans with post-traumatic stress disorder (PTSD) feel better, and it will compare the results with a fake treatment and a group that waits for the treatment.

  NIH research Veterans Health Administration · Long Beach, United States · NIH-10909798

• Using text messages to help reduce PTSD symptoms and hazardous drinking

  This study is testing a new text messaging program designed to help people with PTSD and drinking problems by providing support and therapy techniques right on their phones, making it easier for them to feel better without needing to see a therapist in person.

  NIH research University of Washington · Seattle, United States · NIH-10904690

• Understanding how genes and environment interact in PTSD.

  This study is looking at how our genes and life experiences work together to affect the risk of developing PTSD, with the goal of helping us understand who might be more vulnerable and improving treatment options for those who need it.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10878745

• Investigating the role of gut serotonin transport in PTSD

  This study is looking at how the gut's serotonin transporter might affect PTSD symptoms in veterans, hoping to find new ways to help treat this condition by understanding the connection between gut health and serotonin levels.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-10856911

• The role of sex hormones in post-traumatic stress disorder (PTSD)

  This study looks at how hormones like testosterone and estradiol might affect the development and severity of PTSD and related issues like depression and anxiety, especially in men and women, to help find better ways to treat and prevent these conditions.

  NIH research Stanford University · Stanford, United States · NIH-10842407

• Using neurostimulation to help veterans with severe PTSD

  This study is looking at a new way to help veterans with severe PTSD by using a device that monitors brain activity and helps reduce fear, with the goal of finding a better treatment for their symptoms.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10668215

Related topics

Quick answers

How many Post Traumatic Stress Disorder clinical trials are recruiting right now?

94, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (68 trials), France (6 trials), Canada (5 trials), Israel (4 trials), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 17, Phase 2/3: 3, Phase 3: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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