NOX2 and microglia in brain injury: a potential path to better recovery

Who could benefit from this research

What this research studies

This project looks at how microglia, the brain’s immune cells, stay activated after TBI and contribute to long-term problems. Researchers will use advanced single-cell RNA sequencing to map microglial subtypes and how deleting NOX2 changes their behavior. The goal is to see if reducing NOX2 can shift microglia from a damaging state to a more supportive one, potentially reducing cognitive and motor deficits. The work builds on prior findings that NOX2 is involved in chronic neuroinflammation and neurotoxicity after injury, and that altering microglia can improve outcomes in animal models. The study is designed to translate these insights toward new therapeutic targets for people who have suffered TBI.

Why it matters

Where this research is happening

• University of Maryland Baltimore
  Baltimore, United States Active

Researchers

• Principal investigator: Stoica, Bogdan Adrian — University of Maryland Baltimore
• Study coordinator: Stoica, Bogdan Adrian

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.