Assessing blood clotting disorders in traumatic brain injury patients
The Utility of Thromboelastography for Predicting the Risk of Coagulation-Related Damages Secondary to Traumatic Brain Injury
This study is trying to see how blood clotting problems in people with traumatic brain injuries affect their recovery and outcomes after they arrive at the hospital.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Shanghai 6th People's Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT04524637 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the relationship between post-traumatic hemocoagulation disorders, identified through thromboelastography, and coagulation-related damages in patients with traumatic brain injury. By analyzing patients who arrive at the hospital within 24 hours of head trauma, the study seeks to understand how these disorders impact patient outcomes. The findings will contribute to the development of prediction models or risk scoring systems to better anticipate coagulation-related complications in this population.
Who should consider this trial
Good fit: Ideal candidates are patients who have experienced isolated traumatic brain injury and are admitted to the hospital within 24 hours of the incident.
Not a fit: Patients with pre-existing neurological diseases or known coagulation disorders are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction and management of coagulation-related complications in patients with traumatic brain injury.
How similar studies have performed: While the specific approach of using thromboelastography in this context may be novel, similar studies have indicated the importance of coagulation assessment in traumatic brain injury.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are delivered to hospital within 24 hours after head trauma * Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury Exclusion Criteria: * Patients with existing prior neurological disease * Patients with known coagulation disorders * Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma * Patients receiving blood components prior to blood draw * Patients who deteriorate and die before determining whether coagulation- related damage exists
Where this trial is running
Shanghai
- Shanghai Sixth People's Hospital — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Hao Chen, M.D., Ph.D.
- Email: chenhao_316@aliyun.com
- Phone: 86-21-64369181
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.