Surgery risk calculator for people with cirrhosis
Official title: Development and Validation of a Cirrhosis-specific Surgical Risk Calculator (C-SuRC)
Funded at VA Puget Sound Healthcare System · NIH-11193256 · Data updated 2026-11-12
Building a calculator that estimates the chance of death and complications after surgery for people who have cirrhosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2020 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01HX003062-06 |
| Project ID | NIH-11193256 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with cirrhosis who are planning or considering elective or urgent surgery—especially Veterans receiving care in the VA system—are the ideal candidates for this work.
✕Less likely to help
People without cirrhosis, patients whose care is outside the VA system, or those having rare procedures not well represented in the dataset may not get accurate predictions.
What this research studies
You would get a personalized estimate because researchers are building a cirrhosis-specific surgical risk calculator using a large national VA dataset that links pre-surgery health, liver function, and surgical details to outcomes. The team will combine cirrhosis-related, surgery-related, and other health factors into a prediction model and compare different modeling approaches. They will check the calculator's accuracy and calibration by comparing its predictions to past surgical outcomes. The goal is to help you and your surgical team choose safer options and address treatable problems before surgery.
Why it matters
Potential benefit: If successful, this tool could help patients and surgeons make safer decisions, avoid high-risk operations, and address modifiable issues before surgery to lower complications and death.
How similar studies have gone: Existing general surgical risk calculators have helped surgical decision-making, but a cirrhosis-specific calculator is novel and has not been widely validated.
Where this research is happening
-
VA Puget Sound Healthcare System
Seattle, United States Active
Researchers
- Principal investigator: Ioannou, George — VA Puget Sound Healthcare System
- Study coordinator: Ioannou, George
Related research
Other NIH-funded projects on the same topics.
-
Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
-
Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.