Comparing 3D and 2D MRI techniques for assessing liver cirrhosis and portal hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of three-dimensional magnetic resonance elastography (3D-MRE) compared to two-dimensional magnetic resonance elastography (2D-MRE) in predicting hepatic venous pressure gradient (HVPG) in patients with cirrhosis. The study focuses on developing a non-invasive and accurate method for risk stratification and management of portal hypertension, which is a significant complication of cirrhosis. By analyzing the viscoelastic properties of liver tissue, the researchers hope to establish a reliable prediction system that could improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age \> 18 years old
2. confirmed cirrhosis (laboratory, imaging and clinical symptoms)
3. with 3D-MRE and 2D-MRE within 1 month prior to HVPG measurement
4. written informed consent

Exclusion Criteria:

1. any previous liver or spleen surgery
2. liver cancer; chronic acute liver failure
3. acute portal hypertension
4. unreliable HVPG, 3D-MRE or 2D-MRE results due to technical reasons
5. with liver interventional therapy between HVPG and MRE

Where it's running

• Shengjing Hospital of China Medical University
  Shenyang, Liaoning, China Recruiting

Study contacts

• Study coordinator: Yu Shi
• Email: 18940259980@163.com

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.