EUS-guided measurement of portal pressure gradient

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 1–2 interventional trial uses an endoscopic ultrasound (EUS) approach with a novel device to obtain portal and systemic venous pressures and calculate the portal pressure gradient (PPG). Participants are adults with cirrhosis from chronic hepatitis who meet coagulation and anatomical safety criteria. The procedure aims to offer a direct, less invasive alternative to transjugular hepatic venous pressure gradient (HVPG) measurement and will correlate PPG values with risk of clinical complications. Safety, feasibility, and the relationship between PPG and established clinical outcomes will be recorded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Suffering from chronic hepatitis induced cirrhosis
* Informed consent available

Exclusion Criteria:

* Medical
* Child-Pugh Class C
* Uncorrected platelet count \<50,000
* INR \> 1.5 (natural)
* Anatomical
* Previous transjugular intrahepatic or surgical portosystemic shunt
* Portal vein thrombosis
* Anatomic alterations of the hepatic vasculature that prevent access to the portal vein or intrahepatic portion of the hepatic veins (identified at screening and/or during the endoscopic procedure).
* Previous history of spontaneous bacterial peritonitis within the previous three months
* Portopulmonary hypertension
* Cardiac decompensation
* Endoscopically Confirmed Exclusion Criteria
* Evidence of active GI bleeding (identified at screening and/or during the endoscopic procedure)
* If the volume of ascites in the path of the needle prevents apposition of the gastrointestinal tract and liver.
* Presence of gastric or duodenal ulcers, dieulafoy's lesion or cancers.

Where it's running

• Chinese University of Hong Kong
  Hong Kong, Hong Kong, China Recruiting

Study contacts

• Study coordinator: Anthony Y Teoh, FRCSEd
• Email: anthonyteoh@surgery.cuhk.edu.hk
• Phone: 35052956

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Noninvasive Prediction of Portal Hypertension in Cirrhosis Using STVi

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.