Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
Official title: Evaluating risk factors for cirrhosis progression and response to statin therapy among a cohort of patients with cirrhosis
Funded at University of Miami School of Medicine · NIH-11591513 · Data updated 2026-11-12
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 22, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $338,501 |
| NIH project number | 5U01DK130185-06 |
| Project ID | NIH-11591513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with compensated cirrhosis from various causes who may be considered for statin therapy.
✕Less likely to help
Patients without compensated cirrhosis or those for whom statin therapy is not appropriate may not benefit.
What this research studies
The study will recruit a diverse group of patients with compensated cirrhosis to track how their liver disease progresses over time and what factors influence decompensation. Researchers will examine health conditions, liver disease causes, and how patients respond to statin therapy to identify who may benefit most or face risks. The team will use a large, real-world cohort in the United States to evaluate safety and effectiveness of statins in slowing cirrhosis progression. The goal is to guide future treatment decisions and improve outcomes for people with cirrhosis.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor statin therapy to slow cirrhosis progression and reduce complications for patients with compensated cirrhosis.
How similar studies have gone: Previous data hint that statins might slow progression, but prospective data in diverse US populations are limited.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Goldberg, David Seth — University of Miami School of Medicine
- Study coordinator: Goldberg, David Seth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.