Examining breath markers in liver disease patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the characteristics and prognosis of patients with chronic liver disease, particularly cirrhosis, by analyzing exhaled breath markers such as nitric oxide, hydrogen, methane, and hydrogen sulfide. The study aims to correlate these breath markers with serological tests, gut microbiota analysis, and radiomics to identify new diagnostic biomarkers and therapeutic targets. By understanding the relationship between gut microbiota disruption and liver disease progression, the research seeks to recognize high-risk patients and improve clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

① Patients diagnosed with chronic liver disease or cirrhosis through liver biopsy pathology or clinical laboratory and imaging examinations;

② Undergo molecular breath testing within one week of admission.

Exclusion Criteria:

* Patients who have received antibiotic treatment within one month; ② Patients with severe pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, or lung malignancies that have not been clinically cured; ③ Patients who are unable to successfully complete the molecular breath test.

Where it's running

• Shanghai Geriatrics Medical Center
  Shanghai, Shanghai Municipality, China Recruiting
• Shanghai Minhang District Central Hospital
  Shanghai, Shanghai Municipality, China Recruiting
• Zhongshan Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Shiyao Chen, Ph.D. — Shanghai Zhongshan Hospital
• Study coordinator: Yiting Wang, Ph.D.
• Email: wang.yiting@zs-hospital.sh.cn
• Phone: +86-15221919860

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.