Frailty, Nutrition, and Recovery in People Waiting for a Liver Transplant
Investigation of the Relationship Between Frailty, Sarcopenia, Malnutrition, and Psychosocial Parameters and Post-Transplant Outcomes in Liver Transplant Candidates
This project will test whether measures of frailty, muscle loss, nutrition, and psychological health can predict outcomes for adults (18–65) on the liver transplant waiting list in Turkey.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Izmir Bakircay University Academic / other |
| Locations | 1 site (Izmir) |
| Trial ID | NCT07414095 on ClinicalTrials.gov |
What this trial studies
This observational study enrolls adults listed for liver transplant and collects simple physical tests (strength, walking speed, daily activity), nutrition measures, and psychological screening before transplant. Researchers will link these multidimensional measures to clinical liver scores and track outcomes after transplant such as length of stay, complications, and survival. The design is longitudinal and descriptive, using routine clinical follow-up to relate pre-transplant status to post-transplant recovery. Findings aim to identify high-risk patients who might benefit from targeted pre- and post-transplant support.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18–65 who are listed for liver transplant at the participating center and can understand Turkish and complete simple physical tests.
Not a fit: Patients with severe orthopedic or neurological limitations, active serious extrahepatic malignancy, multiple organ transplants, or inability to follow verbal commands may not benefit from the assessments.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk and tailor nutrition, physical therapy, and psychosocial support to improve recovery and survival.
How similar studies have performed: Previous observational studies have shown that frailty and sarcopenia predict worse outcomes after liver transplant, so this approach builds on existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being listed as a liver transplant candidate * Age between 18 and 65 years * Ability to understand the Turkish language Exclusion Criteria: * Presence of orthopedic and/or neurological problems severe enough to prevent completion of assessment tools * Inability to understand verbal commands * Being a recipient of multiple organ transplants * Presence of serious active extrahepatic malignancy
Where this trial is running
Izmir
- Izmir University of Economics Medical Point Hospital — Izmir, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Assistant Professor
- Email: ayse.vatansever@bakircay.edu.tr
- Phone: 14046
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.