Understanding how human hepatic stellate cells drive liver fibrosis in alcohol-related disease

Who could benefit from this research

What this research studies

Researchers will study liver tissue from patients with alcohol-related liver disease (AALD) and compare it to non-alcoholic fatty liver disease and normal livers using advanced single-cell and chromatin assays. They will look at hepatic stellate cells, which are key players in liver scarring, to identify gene expression and chromatin patterns that specifically drive fibrosis in AALD. The work uses donated human liver tissue from people whose livers were declined for transplantation, focusing on meaningful differences between diseases at the cellular level. Findings could point to targets for therapies that prevent or reverse fibrosis in affected patients.

Why it matters

Where this research is happening

• University of Southern California
  Los Angeles, United States Active

Researchers

• Principal investigator: Kisseleva, Tatiana — University of Southern California
• Study coordinator: Kisseleva, Tatiana

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.