Outcomes of adults with cirrhosis admitted to the general ICU (2014–2024)
Official title: Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
Run by Centre Hospitalier Universitaire de Besancon · NCT06948565 · Data updated 2026-11-12
This project will see if adults with cirrhosis admitted to the ICU from 2014 to 2024 had better survival, access to liver transplantation, and ICU care practices than reported before 2014.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Besancon Academic / other |
| Locations | 1 site (Besançon) |
| Status | Recruiting |
| Started | August 8, 2025 |
| Main results expected | December 2025 |
| Study ends | December 2026 |
| Registry record updated | August 11, 2025 |
| Trial ID | NCT06948565 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age ≥18) with clinically or histologically confirmed cirrhosis who were admitted to the general intensive care unit at the participating hospitals between January 2014 and December 2024.
✕Probably not a fit
Patients under 18, those without cirrhosis, or patients treated outside the participating hospital network would not be included and would not directly benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a regional retrospective multicentre cohort analysis of adult patients with cirrhosis admitted to general intensive care units between January 2014 and December 2024. Medical records from a tertiary centre (CHU de Besançon) and affiliated primary hospitals will be reviewed for admission severity, ICU interventions, application of guideline-based practices, access to liver transplantation, and outcomes including survival. The analysis will compare current outcomes and care practices with data reported in the literature prior to 2014 and will look for variability in patient phenotype and outcomes related to centre resources. No prospective interventions are planned; all adults with clinically or histologically confirmed cirrhosis admitted during the period are eligible for inclusion.
Why it matters
Potential benefit: If successful, the findings could identify care practices that improve survival and transplant access and guide better ICU management for people with cirrhosis.
How similar studies have gone: Previous retrospective cohort studies, including the investigators' earlier pre-2014 publication, have reported improved ICU survival and transplant access for some cirrhotic populations, but results vary by region and centre.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024. Exclusion Criteria: None
Where it's running
-
CHU de Besançon
Besançon, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.