EUS-guided portal pressure measurement as an alternative to hepatic venous pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This investigator-initiated, single-arm prospective study performs both endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) and standard hepatic venous pressure gradient (HVPG) measurements in the same patients. Researchers will compare numeric pressure values to quantify correlation and agreement and will record procedure-related complications to compare safety. Eligible adults (18–85) with suspected or confirmed portal hypertension due to chronic liver disease will undergo both procedures at Hospital Clinic de Barcelona. The aim is to see if EUS-PPG provides clinically comparable portal pressure information while potentially reducing procedural risks and invasiveness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must be 18 to 85 years of age inclusive, at the time of signing the informed consent form.
* Subjects who have a history of liver disease and portal hypertension or suspected cirrhosis requiring HVPG measurement.
* Subjects capable of giving signed informed consent.

Exclusion Criteria:

* Pregnancy.
* Significant bleeding risk (International Normalized Ratio (INR) \> 1.5 OR platelet count \< 50000).
* Presence of active gastrointestinal bleeding at the time of screening
* History of any blood thinner consumption (e.g. warfarin, heparin, novel roal anticoagulants) within the last 5 days.
* Presence of massive ascites causing abdominal distension or requiring frequent therapeutic paracentesis.
* Subjects having received previous Transjugular Intrahepatic Portosystemic Shunt (TIPS) or Surgical Portosystemic Shunt.
* Hepatocellular carcinoma not meeting Milan Criteria.
* Presence of portal vein thrombosis or another suspected component of presinusoidal portal hypertension.
* Presence of extra-hepatic cancer, terminal disease, or severe comorbidities significantly limiting life expectancy or affecting study participation.
* Stenosis or surgical anatomical alterations of the gastrointestinal tract that could preclude endoscopic access with the echoendoscope.

Where it's running

• Hospital Clinic de Barcelona
  Barcelona, Spain Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• EUS-guided measurement of portal pressure gradient

  This study will test an endoscopic ultrasound (EUS) technique to directly measure portal pressure in people with cirrhosis to see if it can safely and accurately indicate portal hypertension.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.