Alcohol-related liver disease research center advances new therapies
Official title: Southern California Research Center for ALPD and Cirrhosis
Funded at University of Southern California · NIH-11397368 · Data updated 2026-11-12
A large, multi-institution effort is exploring how alcohol-related liver disease develops and how to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | December 31, 1998 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,642,313 |
| NIH project number | 5P50AA011999-28 |
| Project ID | NIH-11397368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with alcohol-related liver disease, cirrhosis, or related pancreatic conditions who may participate in future trials or benefit from improved therapies.
✕Less likely to help
Some patients with other liver diseases or those not eligible for emerging ALPD therapies may not benefit.
What this research studies
This grant supports a collaborative hub at USC and partner Southern California institutions that works to understand and combat alcohol-associated liver disease and cirrhosis. Researchers study clinically relevant animal models to uncover molecular mechanisms and test potential treatments. The center has a track record of developing new therapies and training the next generation of scientists in ALPD research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments and better care for people with alcohol-related liver disease and cirrhosis.
How similar studies have gone: Previous efforts have yielded promising therapies and new insights, with ongoing translation to clinical approaches.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Tsukamoto, Hidekazu — University of Southern California
- Study coordinator: Tsukamoto, Hidekazu
Related research
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-
Statin therapy for people with compensated cirrhosis
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-
Liver Cirrhosis Network: Centers for Clinical Research
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-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.