Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
Official title: Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11591516 · Data updated 2026-11-12
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 23, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $623,101 |
| NIH project number | 5U01DK130180-06 |
| Project ID | NIH-11591516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cirrhosis due to alcohol, NAFLD, or other etiologies, including those co-infected with HIV, who are under active follow-up in participating centers.
✕Less likely to help
Patients without cirrhosis or those not followed at participating institutions may not benefit from this study.
What this research studies
If you have cirrhosis, this project will follow people over time to see how their liver disease progresses when HIV is present and whether taking simvastatin changes the course. Researchers will use patient data and clinical information to explore fibrosis, decompensation, and liver cancer risk, with attention to sarcopenia and frailty. The study aims to identify factors that predict worsening health and to understand whether treating the underlying causes can slow or reverse damage. The work may involve monitoring people in clinical settings to better tailor future therapies for cirrhosis, particularly for those with HIV infection.
Why it matters
Potential benefit: If successful, the study could inform personalized care plans and lead to strategies that reduce progression and complications of cirrhosis.
How similar studies have gone: Prior work suggests fibrosis and complications in cirrhosis are influenced by comorbidities, but prospective data on sarcopenia and HIV co-morbidity are limited, making this study novel.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
Related research
Other NIH-funded projects on the same topics.
-
How HIV and simvastatin affect outcomes in people with cirrhosis
This project looks at whether having HIV and taking simvastatin change health outcomes for adults with cirrhosis from different causes.
-
Evaluating outcomes in cirrhosis and the effects of HIV and simvastatin
This study is looking at how simvastatin might help people with liver disease from cirrhosis, especially those who also have HIV, by tracking their health and any changes in their strength and overall well-being over time.
-
Evaluating outcomes in cirrhosis related to HIV and simvastatin treatment
This study is looking at how simvastatin treatment affects people with cirrhosis who also have HIV, to see how it influences their liver health and related issues like muscle loss and weakness, so we can better understand how to help them feel better and improve their condition.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Cardiac health and protein markers in kids with perinatal HIV exposure or infection
A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.
-
HBV cure clues in people with and without HIV
This project studies how HBV-specific B and T cell responses relate to curing hepatitis B in people with and without HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.