A prognostic model that adds nutritional and metabolic measures for liver cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort of adults with cirrhosis enrolled at the Second Affiliated Hospital of Chongqing Medical University. Researchers will collect clinical data, standard liver and renal labs, nutritional scores (BMI, PNI, GNRI), resting energy expenditure, and non-targeted blood metabolomics. Patients will be followed at 3 months, 6 months, 1 year, and 2 years to record survival, hepatic events, and complications. Statistical analyses will identify nutrition- and metabolite-based variables to build and optimize a novel prognostic scoring model for cirrhosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants must meet all of the following criteria to be eligible for this study.

1. Willingness and ability to sign the informed consent form.
2. Male or female, aged 18 to 75 years.
3. A diagnosis of liver cirrhosis that meets the reference criteria of the Chinese Society of Hepatology's "Guidelines for the Diagnosis and Treatment of Liver Cirrhosis".
4. An expected survival of over 3 months.
5. Full civil competence.

Exclusion Criteria:

1. Primary liver cancer diagnosis, or supporting evidence of elevated alpha-fetoprotein (AFP≥100μg/L) for \>3 months, or imaging evidence of hepatic cancer nodules.
2. Malignancy history within 5 years before screening, except for specific cured cancers (e.g., basal cell skin cancer); current or past major illnesses (as defined by the China Insurance Regulatory Commission's 25 critical illnesses) that may affect treatment, assessment, or compliance.
3. Severe pulmonary, cardiac, diabetic, or genetic metabolic diseases.
4. Psychiatric hospitalization, suicide attempts, or temporary disability due to mental illness in the past 5 years.
5. Pregnant or breastfeeding women.
6. Individuals deemed unsuitable by the investigator.

Where it's running

• The Second Affiliated Hospital of Chongqing Medical University
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Study coordinator: juan Kang, M.D.
• Email: 68368892@qq.com
• Phone: +8613996112052

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.