How low blood sugar at night affects muscle loss in cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Cirrhosis reduces liver glycogen and increases gluconeogenesis, which can lead to frequent nocturnal hypoglycaemia and may drive muscle and fat breakdown that worsens sarcopenia. This observational study uses continuous glucose monitoring, dietary collection, clinical tests, and questionnaires to measure the burden of hypoglycaemia and nutritional status in people with cirrhosis. Eligible adults are those followed regularly under EASL-recommended monitoring, with exclusions for recent decompensation, active cancer, recent systemic steroids, or organ transplant. The aim is to correlate hypoglycaemia exposure with objective markers of sarcopenia and undernutrition to inform possible preventive strategies.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age ≥18 years
* Person with oral consent
* Patient with cirrhosis according to the 2021 EASL criteria (1)
* Patient receiving regular six-monthly and systematic monitoring of cirrhosis, according to the European recommendations of the EASL (2), or French recommendations of the TNCD (3) and HAS (4), including a clinical examination, a biological work-up (to calculate the CHILD-PUGH score and monitor alpha-feto-protein), AND requiring imaging to screen for HCC of hepatocellular carcinoma using cross-sectional imaging (by MRI and/or hepatic CT scan).

Exclusion Criteria:

* Patients with active cancer or treated within the last 6 months
* Patient with an acute episode of cirrhosis decompensation (ongoing antibiotic treatment for an active infection, gastrointestinal bleeding, hepatic encephalopathy, acute alcoholic hepatitis) less than one month old.
* Treatment with systemic corticosteroids, in progress or within the last 3 months
* Patient with organ transplant
* Person not affiliated to or not benefiting from a social security scheme
* Person under legal protection (curatorship, guardianship)
* Person subject to a legal protection measure
* Pregnant or breast-feeding women
* An adult who is incapable or unable to give consent
* Minors
* Patients already included in an interventional study who may interfere with the evaluation of this study.

Where it's running

• CHU Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Thomas MOUILLOT
• Email: Thomas.mouillot@chu-dijon.fr
• Phone: 0380293750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.