Vaccination for liver transplant candidates

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients awaiting liver transplantation, who are at increased risk for severe infections due to their compromised immune systems. It aims to evaluate the immunogenicity of vaccines in these patients, ensuring they receive appropriate vaccinations to prevent infections that could complicate their condition. The study involves candidates referred by the hepato-gastroenterology department for pre-transplant evaluation and assesses their vaccination status and response. By updating vaccinations, the study seeks to improve the overall health and safety of liver transplant candidates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 years old
* patients waiting for liver transplantation referred by hepato-gastroenterology department as part of the pre-transplant evaluation to the infectiology consultation
* patient who were informed of the study and did not object to participate

Exclusion Criteria:

* patient candidate for multi-organ transplant
* patient who received immunosuppressive therapy, biotherapy and/ or corticosteroid therapy at a dose greater than 10 mg / day of prednisone equivalent for more than 2 weeks within 3 months before vaccination (6 months of rituximab)
* patient who received polyvalent immunoglobulins within the 6 months before the serological evaluation
* patient who received systemic anti-cancer chemotherapy for solid tumor or hemopathy within 6 months preceding the start of vaccination
* splenectomized patients
* asplenic patients for a reason other than liver disease
* chronic infection with the human immunodeficiency virus (HIV)
* patient with any other hereditary immune deficiency or acquired which could compromise the vaccine response or interpretation of serological results
* patient under legal protection measure or unable to consent to the study

Where it's running

• Service des maladies infectieuses et tropicales - Hôpital de la Croix-Rousse
  Lyon, France Recruiting

Study contacts

• Study coordinator: Florent VALOUR, Dr
• Email: florent.valour@chu-lyon.fr
• Phone: 04 72 07 11 07

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.