Comparing HVPG and endoscopic ultrasound portal pressure measurements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares portal pressure readings from the standard transjugular hepatic venous pressure gradient (HVPG) technique with readings obtained by endoscopic ultrasound-guided portal pressure gradient (EUS-PPG). Participants indicated for HVPG will first have HVPG measured while conscious by one operator, then HVPG repeated under anesthesia by a second operator blinded to the initial values, and finally EUS-PPG will be performed by an endoscopist blinded to prior measurements. The primary aim is to determine whether EUS-PPG provides equivalent gradient accuracy to HVPG. Results could clarify whether EUS-PPG is a reliable alternative for clinical decision-making in portal hypertension.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-75 years at the time of enrollment; signed informed consent
* Clinical indication for HVPG measurement and/or transjugular liver biopsy for chronic advanced liver disease

Exclusion Criteria:

* Severe co-morbidities (e.g., advanced chronic heart failure, chronic renal insufficiency stage 4 and above, long-term poorly compensated diabetes mellitus with severe complications)
* Pregnancy
* Estimated patient non-compliance and/or not signing of the informed consent
* Documented iodine contrast dye allergy
* Presence of portal vein thrombosis or cavernomatous transformation of portal vein or hepatic vein obstruction
* Ascites Grade 3
* Biliary obstruction
* Anticoagulation or antiplatelet therapy, which cannot be discontinued
* INR \> 1.5 and/or platelet count \< 50,000/µl
* Hepatocellular carcinoma in the left lobe of the liver
* Surgically altered upper gastrointestinal tract anatomy
* State after transjugular intrahepatic portosystemic shunt
* State after liver transplantation

Where it's running

• Military University Hospital Prague
  Prague, Bohemia, Czechia Recruiting
• Ikem
  Prague, Czechia Recruiting

Study contacts

• Principal investigator: Petr Hříbek, MD, PhD — Military University Hospital, Prague
• Study coordinator: Petr Hříbek, MD, PhD
• Email: petr.hribek@uvn.cz
• Phone: +420973203065

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.