Using Tranexamic Acid and Vitamin K to Treat Upper Gastrointestinal Bleeding in Cirrhotic Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the effectiveness of Tranexamic acid and vitamin K injections in controlling upper gastrointestinal bleeding (UGIB) among Egyptian patients with liver cirrhosis. Participants experiencing variceal bleeding will be randomly assigned to receive either the active treatment or a placebo, with outcomes measured in terms of bleeding and mortality rates at 5 days and 6 weeks following endoscopic intervention. The study will also ensure that all patients receive standard initial management for their condition. The trial is designed to provide insights into the potential benefits of these interventions in a specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Liver cirrhosis
* Upper gastrointestinal bleeding

Exclusion Criteria:

* Patients aged \< 18 years
* Allergy to tranexamic acid
* Allergy to vitamin K injection
* DIC.
* Thromboembolic event.
* Pregnancy or lactation.
* End-stage renal disease.
* Unwilling to participate in our study.

Where it's running

• Tanta University Hospitals
  Tanta, Gharbyea, Egypt Recruiting

Study contacts

• Principal investigator: Rania M Elkafoury, MD — Tropical medicine and infectious diseases Department, Faculty of Medicine, Tanta University
• Study coordinator: Rania M Elkafoury, MD
• Email: rania.elkafoury@med.tanta.edu.eg
• Phone: +201004672358

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.