Nutritional program to reduce frailty in people waiting for a liver transplant
Official title: Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)
Run by Hospices Civils de Lyon · NCT06911619 · Data updated 2026-11-12
This trial will try a targeted nutritional management program to see if it reduces frailty in adults with cirrhosis who are on the liver transplant waiting list.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 210 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon) |
| Status | Recruiting |
| Started | June 30, 2025 |
| Main results expected | June 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | July 4, 2025 |
| Trial ID | NCT06911619 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) who are registered on the liver transplant waiting list at Croix Rousse Hospital with cirrhosis and an LFI indicating frailty (LFI ≥ 3.2), who can perform the physical tests and provide informed consent, are ideal candidates.
✕Probably not a fit
Patients with an initial LFI indicating robustness (LFI < 3.2), those unable to perform the LFI exercises, patients in intensive care, pregnant or lactating women, or those under legal/psychiatric restrictions are unlikely to benefit or are ineligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults listed for liver transplantation at Hospices Civils de Lyon who are frail or sarcopenic will be offered a dietary management intervention versus usual care. Frailty will be measured using the Liver Frailty Index (LFI), which combines bedside grip strength, chair stand, and balance tests to produce a reproducible score. Participants with an initial LFI below the frailty threshold are excluded and those unable to perform the physical tests are not eligible. The trial compares change in frailty and nutritional status between the dietary management group and the no-dietary-management group during the pre-transplant waiting period.
Why it matters
Potential benefit: If successful, the nutritional program could reduce frailty and sarcopenia before transplant, potentially lowering complications and improving transplant outcomes.
How similar studies have gone: The Liver Frailty Index was validated by Lai et al. in 2017 for measuring frailty in transplant candidates, but evidence that nutrition interventions reliably reverse frailty in cirrhosis is limited and results have been mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged ≥ 18 years * Patient registered on the waiting list for Hepatic Transplantation in the Transplantation center of the Croix Rousse Hospital (GHN), Hospices Civils de Lyon * Dated and signed an informed consent * Affiliated to a social security scheme or beneficiary of a similar scheme Exclusion Criteria: * Patient hospitalized in intensive care * Patient with initial LFI test result \< to 3.2, that is considered as "robust". * Patient unable to perform LFI exercises (chronic or acute motor disability in lower or upper limbs) * Pregnant, parturient or lactating women * Persons deprived of liberty by a judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults subject to a legal protection measure (guardianship, curatorship) * Inability to understand protocol information * Subject participating in another interventional research including an ongoing exclusion period at inclusion
Where it's running
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Hôpital de la Croix Rousse / GHN
Lyon, France Recruiting
Study contacts
- Principal investigator: Maxime PATUREL — Service Rééducation Nutritionnelle Hôpital de la Croix Rousse / GHN
- Study coordinator: Maxime PATUREL, Diététicien, FF CDS
- Email: maxime.paturel@chu-lyon.fr
- Phone: +33 (0)4 72 07 25 43
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.