Natural course of advanced chronic liver disease (cirrhosis)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective-prospective registry that enrolls adults with advanced chronic liver disease or cirrhosis and follows them for up to 10 years. Participants undergo annual transient elastography to measure liver stiffness and clinical data are collected to record incident hepatic events and liver-related mortality. The primary outcomes are new hepatic events and liver-related death, with collected data used to characterize progression patterns and risk factors. Enrollment and follow-up take place at Prince of Wales Hospital in Hong Kong with standard exclusion criteria applied.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 or above
* Known ACLD, defined by:

  * LSM \> 10kPa or
  * Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy.

Exclusion Criteria:

* Current or past history of hepatocellular carcinoma (HCC)
* History of liver transplantation
* Asplenism or history of splenectomy
* Serious medical illness with limited life expectancy of less than 6 months
* Pregnancy
* Unable to obtain or refusal of informed consent from patient

Where it's running

• Prince of Wales Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Jimmy CT Lai, MB ChB — Chinese University of Hong Kong
• Study coordinator: Jimmy CT Lai, MB ChB
• Email: jimmyctlai@cuhk.edu.hk
• Phone: 85235054205

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.