Bumetanide vs. Furosemide for Diuresis in Cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a phase 3, pragmatic interventional trial conducted at the University of Utah Hospital. It compares two loop diuretics, bumetanide and furosemide, in hospitalized patients with cirrhosis and volume overload. Eligible patients are those with a history of cirrhosis who have a diuretic order placed within 24 hours of hospital presentation, excluding those with contraindications or non-volume overload indications. The trial focuses on real-world diuresis outcomes and may inform which diuretic provides more effective fluid removal in this setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* History of liver cirrhosis
* Clinician placed an order for bumetanide or furosemide in electronic health record within 24 hours of presentation to the hospital

Exclusion Criteria:

* Allergy to bumetanide or furosemide
* Contraindication to diuretic administration (e.g. active bleeding, clinical suspicion of hepatorenal syndrome, hypotension)
* Incarcerated or in custody of law enforcement
* Diuretic ordered for purpose other than volume overload (e.g. hyperkalemia, continuation of home medication without clinical signs of volume overload)
* Inpatient admission not anticipated
* Not admitted to an inpatient hospital bed following initial evaluation in the emergency department

Where it's running

• University of Utah Hospital
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Stacy A Johnson, MD — University of Utah
• Study coordinator: Andrea T White, PhD
• Email: andrea.white@hsc.utah.edu
• Phone: 8015817818

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.