Cirrhosis Network study to understand mortality and therapies
Official title: San Diego Cirrhosis Clinical Research Network
Funded at University of California, San Diego · NIH-11591512 · Data updated 2026-11-12
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $359,789 |
| NIH project number | 5U01DK130190-06 |
| Project ID | NIH-11591512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cirrhosis who are treated at participating centers and willing to contribute data and samples.
✕Less likely to help
Patients without cirrhosis or those not meeting enrollment criteria may not benefit from this study.
What this research studies
This project creates a nationwide network to follow diverse patients with cirrhosis over time and collect data across sites. It builds on evidence that certain statins may lower the risk of cancer and decompensation in cirrhosis, and may involve a randomized component to test these medications. The study aims to identify which patients are at highest risk and whether statins could become a standard part of cirrhosis care. Participants may contribute health information and samples to understand disease progression and treatment effects. If successful, this work could guide personalized care and potentially reduce mortality for people living with cirrhosis.
Why it matters
Potential benefit: If the findings are positive, patients with cirrhosis could gain better risk prediction and more effective, evidence-based treatment options.
How similar studies have gone: Past studies suggest statins may reduce cirrhosis complications, but larger randomized trials are needed to confirm benefits.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Loomba, Rohit — University of California, San Diego
- Study coordinator: Loomba, Rohit
Related research
Other NIH-funded projects on the same topics.
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Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.