Evaluating muscle protein metabolism in patients with cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the rates and mechanisms of skeletal muscle protein synthesis and breakdown in patients with cirrhosis. By utilizing multiple tracers administered at short intervals and performing a single muscle biopsy, the researchers seek to identify the molecular regulatory mechanisms responsible for muscle loss in these patients. This innovative approach is expected to advance our understanding of the cellular and molecular responses of skeletal muscle in the context of cirrhosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria.
* Patients with Child Pugh score from A5- to B7
* Control group: Subject in control group should have serum ALT and AST within normal range.

Exclusion Criteria for both groups (cirrhotic and control) are:

* diabetes
* cancer
* kidney failure
* pregnancy
* recent surgery (bowel resection or Gastric bypass operation)
* Advanced cardiac or pulmonary disease
* patient with thyroid disease \& Coagulopathy ( INR \>1.4 and platelet count \<80,000/ml)

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Srinivasan Dasarathy, MD — The Cleveland Clinic
• Study coordinator: Annette Bellar, MSLA
• Email: bellara@ccf.org
• Phone: 2164450688

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Apixaban plus carvedilol to prevent portal-hypertension complications in cirrhosis

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• Copper supplementation for people with cirrhosis

  This trial will try giving copper supplements to adults with cirrhosis who have low copper levels or signs of copper deficiency to see if liver-related health improves.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.