Endovascular treatment outcomes after portal hypertension–related GI bleeding in cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a hybrid observational cohort conducted in Vietnam to describe patient characteristics, treatments, and outcomes after endovascular interventions for portal hypertension–related GI bleeding. It combines a retrospective phase (2021–2026) and a prospective phase (2026–2028) to evaluate technical success, bleeding control, rebleeding, complications, hepatic function changes, and mortality. Procedures include TIPS and obliteration techniques such as CARTO/PARTO and ATO, with choices driven by anatomy and clinical status. The study aims to identify pre-procedural predictors of adverse outcomes and to develop localized prognostic insights for the Vietnamese patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient is aged 18 years or older on the day of admission.
* Confirmed diagnosis of liver cirrhosis by attending clinicians based on clinical findings, laboratory tests, imaging studies (ultrasound, CT, MRI, elastography), or liver histology if available.
* Diagnosis of acute portal hypertension-related gastrointestinal bleeding requiring treatment with at least one endovascular intervention technique (TIPS, PARTO, CARTO, ATO, or combined techniques).
* For patients enrolled in the prospective cohort, signed and dated written informed consent must be obtained prior to study inclusion.

Exclusion Criteria:

* Pregnant or lactating women.
* Non-cirrhotic portal hypertension, or liver cirrhosis that is unconfirmed or questionable.
* Gastrointestinal bleeding due to etiologies completely unrelated to portal hypertension (e.g., peptic ulcer disease, gastric cancer, Mallory-Weiss tears, vascular ectasias), or bleeding of completely unknown origin.
* Missing critical medical records or core pre-procedural/outcome data that would prevent the primary outcome assessment

Where it's running

• University Medical Center Ho Chi Minh City
  Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Study coordinator: Assoc. Professor. Thong Duy Vo, M.D. Ph.D.
• Email: thong.vd@umc.edu.vn
• Phone: +84 932039888

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.