Optimizing Emergency Care for Cirrhosis (OCEAN) in the ED
Official title: The Optimizing Cirrhosis Emergency Care Network (OCEAN)
Funded at Indiana University Indianapolis · NIH-11449805 · Data updated 2026-11-12
A research team at Indiana University Indianapolis is studying how to make emergency care for people with cirrhosis safer, faster, and more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $823,177 |
| NIH project number | 1R01DK143074-01A1 |
| Project ID | NIH-11449805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cirrhosis or advanced chronic liver disease who may visit or require ED care.
✕Less likely to help
Patients without cirrhosis or those not seeking ED care related to liver disease may not benefit.
What this research studies
People with chronic liver disease and cirrhosis often end up in the emergency department and experience high costs, poor quality of life, and increased risk of death. This project uses data from multiple EDs to understand why visits happen and to refine a clinical decision tool that could guide triage and care decisions within 14 to 30 days after ED visits. The goal is to reduce unnecessary visits and improve outcomes for patients and their caregivers. The study will analyze patterns like alcohol-related causes, ascites, and other common ED indications to identify intervention points.
Why it matters
Potential benefit: If successful, it could lead to earlier, more personalized ED triage and outpatient plans that reduce ED visits and improve survival and quality of life for patients with cirrhosis.
How similar studies have gone: Previous work showed gaps in ED management for cirrhosis and a preliminary decision instrument; this project builds on that to validate a broader CDI.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Desai, Archita P. — Indiana University Indianapolis
- Study coordinator: Desai, Archita P.
Related research
Other NIH-funded projects on the same topics.
-
Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
-
Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.