Sponsor or institution
Clinical trials and research at University of Pennsylvania
As of November 12, 2026, Find a Trial lists 184 clinical trials run by University of Pennsylvania that are recruiting, at sites in 11 countries (most in United States (181), Canada (10), South Africa (3)). 3 were first registered in the last 30 days. By phase: Phase 2 (24), Early Phase 1 (11), Phase 1 (10), Phase 4 (7). There are also 2,568 NIH-funded research projects at this institution, with $1.6 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 184Clinical trials
- 2568NIH research projects
- 3New in 30 days
- 11Countries
Newest trials
All recruiting trials (newest 150 of 184)
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Flurpiridaz F-18 PET/CT to Find Parathyroid Adenomas
This study tests whether Flurpiridaz F-18 PET/CT can better detect abnormal parathyroid glands in adults with primary hyperparathyroidism before surgery.
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Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD
A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.
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Safe firearm storage: preferred device choice vs. standard cable locks
This study tests whether giving people a choice of storage devices for firearms leads to safer storage at home compared with just sending cable locks.
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Add-on anti-inflammatory therapy for adults with depression and high inflammation
This study tests whether adalimumab, given with your regular antidepressant Lexapro, can improve depressive symptoms in adults with major depressive disorder and high inflammation.
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FAP PET/CT in adults with pulmonary TB
This early-phase study tests whether a FAP PET/CT scan can map lung fibrosis in adults with pulmonary TB before starting treatment and after cure.
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Gender Inclusive Sexuality Talks for Parents and Teens
This trial tests the GIST program to help parents talk with transgender, gender-diverse, lesbian, or bisexual female youth about sexuality at home.
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Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases
This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.
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Understanding how low-load leg exercises affect muscle and blood flow in PAH patients
This substudy tests whether a gentle leg exercise program can change blood flow and oxygen use in the calf muscles of adults with pulmonary arterial hypertension.
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Chin contour enhancement with hyaluronic acid filler
This study tests whether injecting hyaluronic acid filler into the lower face can restore chin projection and symmetry in adults who want a more defined chin.
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AI-based e-consults: how patients and clinicians choose between human and AI advice in primary care
Older adults and primary care clinicians will compare human versus AI-generated e-consults to see which factors—who gives the advice, wait time, cost, and quality—matter most when deciding which to use.
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Automating Tobacco Cessation in Primary Care
This project tests a workflow in primary care to identify smokers and help them access nicotine replacement therapy (NRT) during routine visits.
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AttunE LIFU for OCD: a non-invasive brain stimulation study
This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.
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Using B-OK Bottles to boost HIV and ART literacy in South Africa
This study tests whether low-cost B-OK bottles help adults in Gauteng understand HIV, ART, and U=U better, compared with standard information or a short video.
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How doctors and nurses decide about bed rest in pregnancy
This study tests a plan to stop routinely restricting activity or bed rest during pregnancy to see if providers accept it, find it appropriate, and change how often they recommend it for women at risk of preterm birth.
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Quinacrine for Cutaneous Lupus Erythematosus
This study tests whether quinacrine can help adults with active cutaneous lupus erythematosus when compared to placebo.
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Helping Parents Talk About Sexuality with Gay or Bisexual Sons
This study tests Parents ASSIST, a five-session online program to help parents communicate about sexuality with their gay or bisexual sons.
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Reward Sensitivity Digital App for Adolescent Suicidal Thoughts
A smartphone app is tested in teens to see if daily check-ins and mood-building activities can reduce suicidal thoughts and improve mood.
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Imaging of the intestinal and central lymphatic system with 18F-FTHA
This study tests an oral radioactive tracer (18F-FTHA) to see how well it can visualize the lymphatic system in healthy adults and in people suspected of having a thoracic duct obstruction.
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Geriatric pelvic ring fracture: see if surgery helps walking patterns
This study tests whether surgical fixation improves walking metrics in older adults with pelvic ring fractures compared to non-surgical care.
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Ketogenic Diet and Alcohol Intoxication: Can ketosis affect brain function and alcohol response
This study tests whether a 4‑week ketogenic diet changes how the brain works and how the body handles alcohol in adults who drink regularly.
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KRAS G12V cancer patients get TCR1188-ABC cell therapy
This early-phase trial tests whether TCR1188-ABC cells can safely be given to adults with KRAS G12V-mutated metastatic cancers to see if it can help some types of pancreatic, biliary, colorectal, or lung cancer.
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Low-intensity focused ultrasound targeting for OCD
This pilot will test whether single sessions of low-intensity focused ultrasound (LIFU) aimed at specific subcortical brain targets are safe, feasible, and change symptoms in adults with chronic OCD.
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Imaging inflammation in abdominal aortic aneurysm using a PET tracer
Researchers are testing whether a new PET tracer, 64Cu-DOTA-ECL1i, can image inflammation in an abdominal aortic aneurysm.
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A smart look at common sleep meds for insomnia
This trial tests how well and how safely widely used sleep medicines and OTCs work for adults with insomnia and which might be best overall.
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Protecting AGYW in Gauteng from Lenacapavir misinformation
This study tests whether a psychological inoculation message can change young women’s intentions to use Lenacapavir as PrEP in South Africa.
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Digital tools to boost HPV vaccination intentions among Nigerian caregivers
This study tests whether different online content can help Nigerian parents of unvaccinated girls ages 9-14 decide to vaccinate their daughters against HPV.
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DAXI for Blepharospasm in Adults
This study tests DaxibotulinumtoxinA (DAXI) to see how long it lasts and how safe it is for adults with blepharospasm who are already getting botulinum toxin injections.
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Office hysteroscopy to diagnose and treat a pregnancy of unknown location
This will test whether office hysteroscopy can safely diagnose and sometimes treat early pregnancies not visible on ultrasound in people with a pregnancy of unknown location.
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Negative Income Tax Trial for MCC students
This trial tests whether a negative income tax helps Omaha MCC students advance in education and work, by giving financial support to eligible students who meet income and enrollment criteria.
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Autologous CD45 base-edited stem cells plus CART-45 cells for relapsed or refractory hematologic cancers
This phase 1 study tests whether a patient’s own edited stem cells and CART-45 cells can be given safely to treat relapsed or refractory B-cell and T-cell lymphomas and Hodgkin lymphoma.
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Home-based exercise to boost fitness for people waiting for a kidney transplant
This study tests whether a 12-week, home-based exercise program plus a wearable activity tracker helps adults on the kidney transplant waiting list increase daily activity and improve physical function.
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Transformative 2.0 for diabetic kidney disease
This project will try to see if adults with diabetic kidney disease who take SGLT2 diabetes medicines have different biological patterns in archived kidney tissue than similar people who do not take these medicines.
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Duloxetine to help mood and function in adults with inflammatory bowel disease
This trial tests whether duloxetine can help reduce anxiety, depression, and IBD-related disability in adults with inflammatory bowel disease.
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Healthy volunteers try a special enteral nutrition plan to see its gut effects
Healthy volunteers will test two eating plans using a complete nutrition formula to see how it changes their gut transit time and microbiome.
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Click & Pick: online shopping policies to help people choose healthier foods
This project will test whether adding taxes, front-of-pack warning labels, and healthy checkout rules on online grocery and restaurant sites helps lower-income adults buy and eat fewer ultra-processed foods.
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Supraglottic airway to support breathing in premature infants born at 29–33 weeks
We will try using a supraglottic airway to give positive-pressure breaths right after birth to premature infants born at 29 0/7–33 6/7 weeks who need help breathing.
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NAD+ Levels in Healthy Adults Before and After Taking NR
This study tests whether taking an over-the-counter nicotinamide riboside (NR) for 30 days changes NAD+ levels in blood and tissue of healthy adults.
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CAR T cells with IL-18 and eDHFR for relapsed or refractory follicular lymphoma
This phase 1 study tests huCART19-IL18-eDHFR cells in adults with follicular lymphoma that has come back or not responded to treatment, to see if they are safe and can work.
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Early General Anesthesia to See if it Reduces PTSD After Cesarean Delivery
This pilot study tests whether switching early to general anesthesia or continuing with IV sedation can help reduce PTSD symptoms in women who have severe pain during cesarean delivery.
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Pre-surgery intratumoral mitazalimab for resectable breast cancer
This test gives a single intratumoral dose of mitazalimab, with or without nivolumab, to adults with resectable stage I–III breast cancer at least 7 days before their planned surgery.
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Mindfulness and stress-management program for adults with sickle cell disease
This program will try a six-week mindfulness and stress-management course to see if it improves quality of life for adults with sickle cell disease who live near Philadelphia.
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Effects of Sleep Loss and Alcohol on Brain and Performance in Healthy Adults
This study tests how sleep deprivation and moderate alcohol use affect thinking and motor skills in healthy adults to understand risks that could relate to spaceflight.
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Adaptive school-based interventions to prevent dental caries in children
This study tests personalized, stepwise prevention strategies in schools to see if they can reduce tooth decay in children aged 5–13.
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Expanding PrEP access using telehealth through community partnerships
This project will try using community organizations as hubs plus telehealth to make it easier for people in the Philadelphia area who could benefit from PrEP to get HIV prevention care.
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Sense4Safety fall-prevention program for older adults with mild cognitive impairment
This project will test whether a home sensor system with machine-learning alerts can detect rising fall risk and help prevent falls in adults 65 and older with mild cognitive impairment.
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Two phone-based approaches to manage high blood pressure after delivery
This trial tests whether two different mobile phone programs help people with pregnancy-related high blood pressure after delivery control their blood pressure, protect heart function, and feel more involved in their care.
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Maintenance combinatorial myeloid immunotherapy with odetiglucan and mitazalimab for unresectable pancreatic cancer
This study will try a combination immunotherapy (odetiglucan plus mitazalimab) as maintenance treatment for adults with unresectable pancreatic cancer whose disease has not progressed after 4–6 months of first-line chemotherapy.
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Texting AI support for early pregnancy care in Philadelphia
This project will test whether a texting conversational AI (CIRCA) can recruit and support people in early pregnancy in the Philadelphia area.
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Menstrual cycle effects on TMS-induced brain plasticity
This protocol will test whether menstrual cycle phase changes how the motor cortex responds to transcranial magnetic stimulation in healthy adults aged 20–40 and will compare responses between men and women.
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Real-time fMRI neurofeedback to reduce negative attention bias in depression
This trial will see if cloud-based real-time fMRI neurofeedback can reduce negative attention bias and improve depressive symptoms in adults with major depressive disorder who are not taking psychiatric medications.
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How pulmonary arterial hypertension affects lean muscle mass
This study will see if PAH is linked to muscle loss and whether that loss affects activity, quality of life, and hospital visits in people with PAH.
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Using patient blood cells to test whether PIP-2 calms immune activation in ARDS
This project will test whether a drug called PIP-2 can calm overactive immune cells taken from people with ARDS.
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MOv19-BBz CAR T cell treatment for FRa-positive lung cancer
This trial will test whether a single intrapleural infusion of MOv19-BBz CAR T cells given after lymphodepleting chemotherapy is safe and can help control FRa-positive metastatic or recurrent non-small cell lung cancer with malignant pleural effusion.
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Ruxolitinib for adults with previously treated idiopathic multicentric Castleman disease
This trial will try ruxolitinib (Jakafi) in adults with iMCD who did not improve with or cannot take siltuximab or tocilizumab.
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Early Non-Invasive Ventilation in ALS
This study tests whether starting non-invasive ventilation earlier in adults with ALS can help improve breathing and quality of life.
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Comparing the MAMMOMAT B.brilliant and Revelation mammography systems
We will try two FDA‑approved mammogram machines to see which shows suspicious breast calcifications more clearly in women having diagnostic mammography.
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Reletex Reliefband plus ERAS to reduce nausea after robotic sleeve gastrectomy
This trial will test whether wearing the Reletex Reliefband in addition to standard ERAS care can reduce nausea and vomiting in adults having robotic sleeve gastrectomy.
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Footsteps app to improve behavioral data collection, supervision, and student outcomes
This test will see if a smartphone app called Footsteps helps school aides collect better behavior data and improves outcomes for students aged 3–17 who receive one-to-one support.
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Dorzagliatin for people with cystic fibrosis and pancreatic insufficiency
This study will test whether taking dorzagliatin twice daily for 7 days improves blood sugar control in adults with cystic fibrosis, pancreatic insufficiency, and abnormal glucose tolerance compared with placebo.
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Penny COPILOT texting support for pregnant and postpartum people with opioid use disorder
This project will try a two-way SMS chatbot called Penny COPILOT to provide support and improve engagement for pregnant and postpartum people with opioid use disorder.
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Using Transcranial Magnetic Stimulation and Language Therapy to Improve Speech After Stroke
This study is testing if combining a brain stimulation technique with speech therapy can help people who have had a stroke improve their speech during the early recovery phase.
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Comparing kidney risk of vancomycin with piperacillin-tazobactam versus vancomycin with cefepime in hospitalized adults
This study will test whether combining vancomycin with piperacillin-tazobactam causes about the same risk of acute kidney injury as combining vancomycin with cefepime in hospitalized adults with suspected or confirmed infection.
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Collecting sputum samples at home for cystic fibrosis patients
This study is testing if collecting sputum samples at home can help people with cystic fibrosis better identify lung infections compared to traditional methods done at the clinic.
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Comparing five immunomodulatory treatments for relapsing polychondritis
This project will try commonly used immune-suppressing medicines to see which best controls mild-to-moderate relapsing polychondritis.
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Evaluating chest tube size and daily lavage for traumatic hemothorax treatment
This study is testing whether using different sizes of chest tubes and daily washing can improve recovery for patients with bleeding in the chest after a trauma.
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Investigating a new radiotracer for brain tau protein in neurodegenerative diseases
This study is testing a new imaging tool to see how well it can detect a specific brain protein linked to various neurodegenerative diseases in people who have these conditions and healthy individuals.
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Understanding Williams Syndrome and related chromosome variants
This study is looking to learn more about the development, health, and behavior of people with Williams syndrome and related chromosome changes by collecting samples and information from them and their families.
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Intra-arterial tenecteplase to improve small-vessel blood flow after mechanical clot removal
This study will try a single weight-based intra-arterial dose of tenecteplase after successful mechanical thrombectomy to improve microvascular blood flow in adults with anterior large-vessel ischemic stroke.
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Finding the right methadone loading dose for people with fentanyl opioid use disorder
This trial tests whether giving a higher 'loading' methadone dose in a monitored setting helps adults with fentanyl opioid use disorder start methadone more safely and comfortably than standard dosing.
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A program to improve social skills in adults with autism
This study is trying out a new program called TUNE In to see if it can help adults with autism improve their social skills and feel more comfortable in everyday situations.
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Low‑dose oral contraceptives plus resistant starch for metabolic health in PCOS
This study will test whether adding resistant starch to standard low‑dose oral contraceptives improves cardiometabolic markers and the gut microbiome in overweight women aged 18–40 with PCOS.
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Brain activity in movement disorders: basal ganglia, thalamus, and cerebellum
We will record brain electrical signals from adults with movement disorders, both with and without deep brain stimulators, to see if specific signal patterns match their symptoms.
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Peer-led harm reduction intervention for opioid use disorder in hospitals
This study is testing a new peer support program in hospitals to see if it can help people with opioid use disorder have fewer overdoses and infections compared to regular care.
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Using Transcranial Magnetic Stimulation and Language Therapy to Improve Mild Aphasia
This study is testing whether combining brain stimulation with speech therapy can help people with mild aphasia after a stroke improve their speaking and understanding skills.
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Supportive housing program for people with HIV
This study is testing a supportive housing program for people with HIV to see if it helps them manage their health better and stay in stable housing.
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Psilocybin effects on motivation and cognitive flexibility in opioid use disorder
This study will test whether a low (1 mg) or high (25 mg) dose of psilocybin changes brain circuits tied to motivation and decision-making in adults with opioid use disorder who are in residential treatment.
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Effects of a ketone supplement on brain power and drinking in alcohol use disorder
In people with alcohol use disorder, this study tests whether a ketone supplement called Kenetik, vs a placebo, can change brain function and reduce alcohol consumption.
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Comparing nasal and oral breathing during drug-induced and natural sleep
This study is testing whether the way people with obstructive sleep apnea breathe (through their nose or mouth) during drug-induced sleep matches how they breathe during natural sleep.
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Measuring glutamate changes after ketamine to explain its fast antidepressant effects
This trial will see if ketamine produces measurable changes in brain glutamate in adults with treatment-resistant major depressive disorder using high-field GluCEST imaging.
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Enhanced community health worker program for cardiovascular disease management
This study is testing a new program that helps people with heart disease in Philadelphia learn to manage their health better by providing extra support from community health workers.
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Development and evaluation of advanced photon-counting CT technology
This study is testing a new type of CT scan that uses less radiation and provides clearer images to see if it can improve diagnosis for patients needing routine scans.
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Motivating Physical Activity in HFpEF with Gamification and Social Incentives
This trial will test whether gamified programs with either social support or friendly competition help adults with HFpEF increase their daily physical activity.
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Depo-Provera (depot medroxyprogesterone acetate) for pain and biomarker changes in women with sickle cell disease
This study will test whether an injectable birth control (Depo-Provera) can reduce pain in adult women with sickle cell disease.
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Autobiographical memory in people with opioid use disorder
This trial tests whether a four-week at-home memory-training program (MemFlex) can improve memory and related symptoms in adults with opioid use disorder while measuring brain and heart activity before and after.
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Coping Skills Training for Emotional Support in COPD Patients
This study is testing a Coping Skills Training program to see if it can help people with COPD feel less depressed and anxious compared to a shorter education program.
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Improving care for mothers with opioid use disorder and their infants in NICUs
This study is trying to see if a new treatment plan for mothers with opioid use disorder can help them and their babies in the NICU feel better and get the care they need.
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Improving surgical access for patients with primary hyperparathyroidism
This study is testing if helping patients with primary hyperparathyroidism get better support and guidance can improve their chances of getting timely surgery.
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Ketone supplement to reduce alcohol withdrawal symptoms and change brain metabolism
This will test whether a 4-day oral ketone supplement can reduce alcohol withdrawal symptoms and alter brain metabolism in adults with moderate to severe alcohol use disorder during inpatient detox.
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Support for Suicide Intervention Officers in the Army National Guard
This study is testing whether extra training or a supportive community helps Suicide Intervention Officers in the Army National Guard better prevent suicide among soldiers.
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Evaluating healing after root-end surgery using L-PRF
This study tests if using a special treatment called L-PRF during root-end surgery can help patients with ongoing tooth problems heal better and faster.
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Understanding how the brain's posterior cingulate cortex affects memory decisions
This study is trying to see how different parts of a brain area called the posterior cingulate cortex affect memory decisions in people with epilepsy.
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Understanding pain relief variability after wisdom tooth extraction
This study looks at how well ibuprofen helps people manage pain after getting their wisdom teeth removed and who might need extra pain relief to avoid using opioids.
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Healing after dental implant placement in patients using TNF-alpha inhibitors
This study is testing how well dental implants heal in patients taking TNF-alpha inhibitors compared to those who aren't, to see if there are any differences in complications and pain after the procedure.
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Examining how skin color affects pulse oximeter accuracy in children
This study is testing how well pulse oximeters work for children with different skin colors during heart procedures to see if their readings are accurate.
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Support for new parents in the NICU
This study tests whether having a doula to support new parents in the NICU can help reduce stress and anxiety for those with preterm infants, especially for families from low-income backgrounds.
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Managing placenta accreta spectrum while preserving the uterus
This study is testing a new way to manage placenta accreta spectrum disorders by allowing some women to keep their uterus after delivery instead of having surgery, to see if it can be a safer option for them.
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Using SGLT1/2 inhibitors to improve heart imaging in healthy volunteers
This study is testing whether a new diabetes medication can help improve heart imaging in healthy volunteers by better controlling how the heart uses sugar during scans.
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Improving antidepressant adherence in primary care patients
This study is testing whether sending personalized daily text messages, with or without cash rewards, can help people with depression stick to their antidepressant medication better than regular care.
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Improving care for HIV patients by addressing structural racism and discrimination
This study is trying to see if changing the way clinics treat patients can improve HIV care for racial and ethnic minorities who are facing discrimination.
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Improving Pre-Anesthesia Care Discussions for Hip Fracture Surgery
This study is testing a new way to help doctors and patients talk about anesthesia choices for hip fracture surgery to see if it improves decision-making and communication.
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Using aspirin to prevent pregnancy loss and preeclampsia
This study is testing if starting low-dose aspirin early in pregnancy can help women at risk for pregnancy loss and preeclampsia have healthier pregnancies.
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Starting buprenorphine treatment for opioid use disorder in patients using fentanyl
This study tests if starting buprenorphine treatment for people with opioid use disorder who are using fentanyl can be done safely without causing withdrawal symptoms.
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Advancing genomic medicine using electronic health records
This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.
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Investigating a new radiotracer for brain imaging in Parkinson's disease and related conditions
This study is testing a new brain imaging tool to see if it can help identify abnormal protein deposits in the brains of people with Parkinson's disease and similar conditions.
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Home exercise program using mobile technology for patients with a HeartMate 3 device
This study is testing whether a home exercise program using mobile technology can help people with a HeartMate 3 device feel stronger and improve their quality of life compared to those who just get regular care.
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Testing a topical treatment for pilonidal disease
This study is testing a new cream to see if it can help people with pilonidal disease feel better and reduce their symptoms.
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Integrated maternity care model to reduce severe maternal morbidity in BIPOC patients
This study is testing a new maternity care model that combines prenatal care with social services to see if it can help reduce serious health problems for Black, Indigenous, and people of color during and after pregnancy.
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Exploring brain stimulation to reduce PTSD symptoms
This study is testing whether a type of brain stimulation can help reduce symptoms of arousal in people with PTSD during therapy.
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Natural history study of LCAT deficiency
This study is looking to find people with LCAT gene mutations to learn more about their health history and how the condition affects them over time.
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Improving care transitions for Medicaid patients with serious mental illness
This study is testing a new care program for people with serious mental illness on Medicaid to see if providing home care right after they leave the hospital helps them stay healthy and avoid going back to the hospital.
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Identifying blood biomarkers for obstructive sleep apnea using microRNAs
This study is testing if certain blood markers can help identify obstructive sleep apnea in people by looking at tiny molecules called microRNAs.
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Virtual health coaching for caregivers of older adults
This study is testing whether virtual health coaching can help caregivers of older adults take better care of themselves after their loved ones leave the hospital.
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Using brain and cognitive tools to understand opioid use disorder
This study is trying to see how opioid use disorder affects thinking and decision-making in people who are stable on medication, to help improve treatment success and prevent relapse.
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Using brain stimulation to improve language skills after stroke
This study is testing whether a type of brain stimulation can help people with language problems after a stroke improve their speaking and understanding skills.
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Imaging and diagnostic assessments for tauopathies
This study is testing new brain imaging tools to see if they can help identify different types of brain diseases in people with Parkinson's and other related conditions.
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Flexible dosing of levothyroxine in older adults
This study is testing if older adults on thyroid medication feel better with a lower or higher target for their thyroid hormone levels over six months.
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Program to improve heart health in patients with high blood pressure and cholesterol
This study is testing a six-month program to help people with high blood pressure and cholesterol improve their heart health using new support tools and strategies.
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Investigating brain uptake of a new radiotracer in tauopathies
This study is testing a new brain imaging tool to see how well it can detect abnormal protein deposits in the brains of people with Multiple System Atrophy, Parkinson's disease, and progressive supranuclear palsy, compared to healthy individuals.
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Improving education for patients needing hemodialysis access
This study is testing different ways to educate patients with advanced kidney disease about getting the right access for hemodialysis to see which method helps them understand and prepare the best.
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Using pregabalin and lofexidine to help treat opioid withdrawal in outpatients
This study is testing if a combination of two medications, pregabalin and lofexidine, can help adults with opioid use disorder feel better during withdrawal and make it easier for them to start a new treatment.
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New treatment combining stem cell transplant and CAR T-cell therapy for acute leukemia
This study is testing a new treatment that combines a stem cell transplant with special CAR T-cells to see if it can help people with hard-to-treat acute myeloid leukemia.
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Comparing two methods of glaucoma drainage device implantation
This study is testing whether placing a glaucoma drainage device in the front part of the eye or in a different spot helps people with glaucoma manage their eye pressure and cell health better over time.
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Using MRI to detect inflammation in giant cell arteritis
This study is testing if MRI scans can help find inflammation in the arteries of people with giant cell arteritis.
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Using a smartphone app to track symptoms in burning mouth syndrome patients
This study is testing a smartphone app to help people with burning mouth syndrome track their symptoms and saliva changes over 12 weeks.
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Using Sildenafil to Improve Blood Flow in Chronic Traumatic Brain Injury
This study is testing whether sildenafil can improve blood flow in people with chronic traumatic brain injury to see if it helps their symptoms.
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Evaluating carotid plaque components using advanced CT imaging
This study is testing a new type of CT scan to see if it can better identify different parts of carotid plaque in stroke patients, which may help understand the link between plaque makeup and stroke risk.
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Outpatient cervical ripening using a Foley catheter
This study is testing if using a Foley catheter at home to help prepare the cervix for labor can reduce the need for C-sections and improve safety for first-time moms and their babies.
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Using semaglutide to treat advanced lung disease
This study is testing if a diabetes and weight loss medication called semaglutide can be safely used by adults with advanced lung diseases to see if it helps them manage their weight better.
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Monitoring symptoms in patients undergoing hemodialysis
This study is testing a new system that helps patients on hemodialysis report their symptoms more easily to see if it improves their care compared to regular check-ups.
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Longitudinal investigation of central nervous system vasculitis
This study is trying to learn more about primary central nervous system vasculitis by following patients over three years to see how the disease affects them and to find better ways to measure its activity and outlook.
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Assessing brain changes after traumatic brain injury over three years
This study looks at how brain tissue changes over three years in people who have had a traumatic brain injury compared to healthy individuals.
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Using Tau PET/CT Imaging to Understand Alzheimer's Disease
This study is testing how Tau PET/CT scans can help us understand the differences in symptoms and brain changes in older adults with Mild Cognitive Impairment or Alzheimer's Disease.
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Deep brain stimulation for severe obsessive-compulsive disorder
This study is testing if deep brain stimulation can help people with severe obsessive-compulsive disorder who haven't found relief from other treatments.
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Comparing magnetic stimulation methods for treating ventricular tachycardia storms
This study is testing two different types of magnetic stimulation treatments to see which one helps people with ventricular tachycardia storms feel better compared to a fake treatment.
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Imaging tau accumulation in neurodegenerative diseases using PI-2620
This study is testing a new type of brain scan to see how tau protein builds up in people with certain types of dementia and in healthy older adults.
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Comparing two non-invasive ventilation methods for preterm infants after extubation
This study is testing whether a new breathing support method is better than a standard one for extremely preterm infants who are coming off a ventilator to see if it helps them avoid complications.
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Personalized brain stimulation to reduce negative emotions
This study is testing if personalized brain stimulation can help people with negative emotions like anxiety and depression feel better by targeting their specific brain patterns.
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Evaluating the effects of a nerve block on heart rhythm issues
This study is testing if a nerve block can help improve heart rhythm problems in people with ventricular tachycardia during a planned heart procedure.
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Effects of Hormones on OCD Treatment with Exposure and Response Prevention
This study is testing how hormonal changes during the menstrual cycle affect the success of a therapy for obsessive-compulsive disorder (OCD) in both men and women.
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Changes in brain connectivity after theta burst stimulation
This study tests how a specific type of brain stimulation can change the way different parts of the brain connect and communicate in healthy people.
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Using Tadekinig Alfa to treat severe side effects from CAR T cell therapy
This study is testing if a new drug called Tadekinig alfa can help people who have severe side effects from CAR T cell therapy feel better.
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Behavioral intervention for chronic insomnia in long-term sleeping pill users
This study is trying a new coaching program to help people who have been using sleeping pills for a long time improve their sleep habits and reduce their dependence on medication for chronic insomnia.
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Using amantadine to help stroke recovery
This study tests if the medication amantadine can help people recover better after having a stroke.
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Testing Empagliflozin and Potassium Nitrate for Heart Failure with Preserved Ejection Fraction
This study is testing if a combination of two medications, Empagliflozin and Potassium Nitrate, can help people with heart failure feel stronger and exercise better.
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Understanding immune responses to influenza vaccination in healthy adults
This study is testing how well the flu vaccine works in healthy adults of different ages to see if their immune responses vary based on when they were born.
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Naltrexone treatment for heavy drinkers with Alcohol Use Disorder
This study is testing if a long-acting injection of naltrexone can help heavy drinkers cut back on their alcohol use.
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Database for Parkinson's Disease and Related Disorders
This study is creating a detailed database of information from people with Parkinson's disease to help researchers understand how the disease progresses and how different treatments work over time.
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Evaluating the use of transesophageal echocardiography in critically-ill patients
This study tests how using a special heart ultrasound called transesophageal echocardiography can help critically-ill patients in emergency and intensive care settings.
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Observational study on relapsing polychondritis
This study is looking to learn more about relapsing polychondritis by regularly checking in with participants to see how the disease affects them and to find better ways to diagnose and treat it.
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Improving exercise endurance in heart failure patients
This study is testing if Potassium Nitrate, with or without extra supplements, can help people with heart failure improve their exercise endurance and muscle function.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
NIH-funded research (newest 40 of 2568)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Comparing universal and guideline-directed genetic testing for young adults with cancer
This study is looking at whether a broader genetic test can help young adults with cancer find inherited risks that regular tests might miss, so they can get better treatment and care tailored just for them.
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Better, searchable data for human pain biology
A data integration center will standardize, combine, and share molecular and cellular data from human pain research to help scientists understand how pain works and to accelerate discoveries.
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Understanding how sweat glands form and work to help burn and skin injury patients
A study at the University of Pennsylvania looks at how sweat glands develop and function, with the goal of informing treatments for people who suffer traumatic skin injuries.
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Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
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Understanding how a special airway cell helps protect and repair breathing passages
A researcher is studying a newly found airway cell called the hillock to see how it protects the airways and helps repair them after injury, with the aim of helping people with asthma, COPD, or bronchiectasis.
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Defining TMJ cartilage progenitors and their regulatory niche for TMJ regeneration
Researchers are studying the cells that could help repair the jaw’s cartilage in TMJ osteoarthritis to lay the groundwork for regenerative therapies.
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Optical control of the actin cytoskeleton for cellular function
A scientist is developing light-activated molecules to precisely control how actin filaments behave in human and animal cells.
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Human pain center study to map normal and migraine-trigeminal neurons
A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.
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Understanding human pain neurons to improve migraine care
Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.
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Epilepsy Data Ecosystem: A Big-Data Sharing Platform for Better Care
A national effort to collect and share large, multi‑modal brain data from people with medication‑resistant epilepsy to speed discoveries and improve treatment options.
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Early HIV treatment with antibodies to boost immune protection
This grant tests whether starting HIV treatment early and giving a special antibody can strengthen the body's immune response and shrink the virus reservoir for better long-term control.
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MXene EEG electrodes to improve brain monitoring
Aims to validate a new, dry MXene-based EEG electrode system that could make brain monitoring simpler, more comfortable, and usable at home or in clinics.
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Personalized Achilles tendon rehab: how loading in daily life affects healing
A person with mid-substance Achilles tendinopathy could benefit from a personalized rehab plan based on how their daily activities load the tendon.
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Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Targets
This grant explores how rare SFTPC mutations in alveolar cells may drive IPF and seeks new molecular targets to improve treatment.
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Behavioral strategies to improve hypertension diagnosis and treatment in India
A behavioral science approach tests simple strategies to help adults in India learn about hypertension, get diagnosed, and stay on treatment.
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Behavioral strategies to boost hypertension diagnosis and treatment in India
A plan to use behavioral science methods to help people in India learn they need treatment for high blood pressure and to start and continue care.
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Meaningful integration and sharing of human pain data to help patients
A coordinated effort to create and openly share a comprehensive, standardized dataset of human pain biology to help researchers develop better pain treatments.
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Data Core supports a national effort to map human pain genes in migraine patients
This grant funds a data core to store and analyze genetic and neural data from human trigeminal neurons to better understand migraine.
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Human Tissue Core for Pain Research at Penn HPPC
A dedicated center at the University of Pennsylvania will collect, store, and share human trigeminal tissue to study migraine biology and pain signaling.
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Integrated single-nucleus multi-omics to map human trigeminal ganglion biology
This NIH grant aims to create detailed molecular maps of human trigeminal ganglion cells under normal and migraine conditions to help find new ways to treat headaches.
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Single-soma RNA sequencing and spatial mapping of human trigeminal ganglia
This grant studies human trigeminal ganglion cells from people with migraine to map which genes and cells are involved in migraine pain.
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Administrative Core of the Penn HPPC to advance precision pain research
A focused administrative core supports a center studying human trigeminal pain pathways to help improve migraine understanding and future treatments.
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Understanding human pain neurons to improve migraine treatment
Researchers are studying human pain-sensing neurons to uncover what goes wrong in migraine and how to target it better.
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Cesarean risk calculator rollout during labor induction
A multi-site plan to use a calculated cesarean risk score during labor induction to help clinicians and patients make more objective decisions and reduce disparities.
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Ethical Multimodal AI for Obesity, Diabetes and Digestive Disease
A Penn team is building safe, multimodal AI tools using medical data to help care for obesity, diabetes, and digestive diseases.
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Plasminogen and podocyte protection in proteinuric kidney disease
A study at UPenn explores how plasminogen affects podocytes in proteinuric kidney disease and tests a urine biomarker and amiloride-based compounds as potential ways to protect kidney function.
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Southeastern Pennsylvania Prevention Epicenter Network
A nationwide network in southeastern Pennsylvania aims to improve prevention strategies for adults and children who have or are at risk for health problems.
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CureGN-Penn Pediatric/Adult Glomerular Disease Registry and Cohort
A large, long-term study from CureGN to better understand how common kidney diseases affect both kids and adults and to help others in the future through shared data and samples.
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CureGN-Penn PCC: A patient-focused study on kidney diseases like FSGS, IgAN, MCD, and MN
A large, long-term study from CureGN is following adults and children with common kidney diseases to understand how the diseases progress and how treatments affect them.
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CureGN-Penn Pediatric and Adult Glomerulonephropathy Registry
A large, long-term study following adults and children with glomerular diseases to understand how these conditions develop and respond to treatment.
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Asian Cohort for Alzheimer's Disease (ACAD) program to study genetics and biomarkers in Asian Americans
A national study will enroll thousands of older Asian Americans to study genetic and biomarker clues about Alzheimer's disease and related dementias.
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Asian Cohort for Alzheimer’s Disease (ACAD)
A large study will recruit Asian Americans or Canadians with Alzheimer’s-related concerns to study genetic and biomarker clues to the disease.
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Asian Cohort for Alzheimer’s Disease (ACAD)
A large U.S. and Canada study aims to collect genetic and biomarker data from 5,081 older Asian Americans to better understand Alzheimer’s disease in this population.
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Exposome-on-a-chip: understanding hesperidin’s effect on bone and BMP function
A study at the University of Pennsylvania will explore how a natural compound in citrus, hesperidin, interacts with bone healing signals to improve bone regeneration using a tiny, biology-on-a-chip system.
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HeartShare: Deeply profile heart failure to find subtypes and targeted treatments
A large study in adults with heart failure aims to create a very detailed picture of different heart failure types to guide more personalized treatments.
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Understanding the human virome through deep RNA sequencing
Researchers are using advanced RNA sequencing to map RNA viruses living in our bodies, helping us understand how these invisible players affect health.
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Shared benchmarking specimens for human virome research
Aimed at creating standard, well‑characterized samples to compare different virus-detection methods used in human virome research.
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Understanding how genetic variants shape gene networks in heart-related cells
This project tests how non-coding genetic differences influence how heart-related cells regulate gene activity and respond over time.
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Diaphragm-driven Ventilatory Assist for Preterm Babies
A new diaphragm-initiated ventilation approach aims to reduce lung injury in preterm infants with breathing support.
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Carbapenemase-Producing Enterobacterales in Companion Animals: A Five-Year Update
This project follows dogs and cats over five years to see how common and diverse carbapenem-resistant bacteria are in pets and how they might connect to human health.
Quick answers
How many clinical trials run by University of Pennsylvania are recruiting right now?
184, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 11 countries. The most sites are in United States (181 trials), Canada (10 trials), South Africa (3 trials), Germany (3 trials), Japan (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 24, Early Phase 1: 11, Phase 1: 10, Phase 4: 7. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.