Monitoring symptoms in patients undergoing hemodialysis

Comparative Effectiveness of Two Approaches to Symptom Monitoring in Hemodialysis

NA · University of Pennsylvania · NCT05738330

This study is testing a new system that helps patients on hemodialysis report their symptoms more easily to see if it improves their care compared to regular check-ups.

Quick facts

PhaseNA
Study typeInterventional
Enrollment2400 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Pennsylvania (other)
Locations1 site (Waltham, Massachusetts)
Trial IDNCT05738330 on ClinicalTrials.gov

What this trial studies

The SMaRRT-HD trial is a cluster randomized trial that evaluates the effectiveness of a symptom monitoring system in hemodialysis patients compared to usual care. Approximately 2400 patients from 30 diverse hemodialysis clinics across the US will participate. The trial utilizes an electronic patient-reported outcome measure (ePROM) system to regularly assess symptoms and facilitate clinician follow-up, aiming to reduce unrecognized symptoms and improve communication between patients and care teams. Clinics assigned to the SMaRRT-HD group will implement this system for a duration of 12 months.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who are currently receiving hemodialysis treatment and can communicate in English or Spanish.

Not a fit: Patients who are unable to report their symptoms using the SMaRRT-HD platform or have conditions that impair their comprehension may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce patient suffering and improve health outcomes for individuals undergoing hemodialysis.

How similar studies have performed: Other studies have shown promise in using symptom monitoring systems in chronic disease management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18 years
* Treatment with hemodialysis at a participating dialysis clinic
* English or Spanish speaking

Exclusion Criteria:

* Not willing to report their symptoms using the SMaRRT-HD platform
* Not willing to share clinically acquired data with the research team
* Underlying condition such as dementia that is anticipated to prevent comprehension of the trial information document (fact sheet)
* Incarceration

Where this trial is running

Waltham, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: End Stage Kidney Disease, End stage kidney disease, Kidney, Hemodialysis, Dialysis, Symptom monitoring, Electronic Patient-Reported Outcome Measure

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.