HeartShare: Deeply profile heart failure to find subtypes and targeted treatments
Official title: HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers
Funded at University of Pennsylvania · NIH-11529337 · Data updated 2026-11-12
A large study in adults with heart failure aims to create a very detailed picture of different heart failure types to guide more personalized treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 10, 2021 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $380,570 |
| NIH project number | 3U01HL160277-05S1 |
| Project ID | NIH-11529337 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years or older with heart failure (HFpEF) and matched comparator participants.
✕Less likely to help
Individuals without HFpEF or who do not participate in deep phenotyping or biosample collection may not directly benefit.
What this research studies
This project will enroll about 1,000 adults with heart failure with preserved ejection fraction (HFpEF) and suitable comparators to build a comprehensive, multi-layer profile of their condition. Researchers will collect rich clinical data, patient-reported outcomes, heart and body systems imaging, and biosamples for multi-omics analysis to uncover distinct subgroups. Advanced bioinformatics will integrate these data to identify potential treatment targets tailored to each subgroup. The study continues a long-term effort to define how different mechanisms contribute to symptoms and outcomes in HFpEF and to translate findings into precision therapies.
Why it matters
Potential benefit: If successful, patients with HFpEF could receive more targeted and effective treatments based on their specific disease subtype.
How similar studies have gone: Previous deep-phenotyping efforts have shown promise in identifying HF subtypes, but this project aims for a more comprehensive, multi-omics approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Chirinos Medina, Julio Alonso — University of Pennsylvania
- Study coordinator: Chirinos Medina, Julio Alonso
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.