Testing a topical treatment for pilonidal disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blinded, placebo-controlled trial aims to evaluate the efficacy of clascoterone, a topical anti-androgen, in treating pilonidal disease. Participants will apply either clascoterone or a placebo cream to the affected area twice daily for 12 weeks. The study will assess changes in disease severity, patient symptoms, and inflammation through physician evaluations and patient surveys. Recruitment will occur at the University of Pennsylvania's colorectal surgery clinics, involving a thorough informed consent process and regular assessments throughout the study duration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 and above
* Diagnosis of Pilonidal Disease
* Willingness to comply with study procedures and availability for duration of study
* Ability to apply topical medications and willing to adhere to regimen

Exclusion Criteria:

* Current use of any topical medication to natal cleft
* Presence of pilonidal-associated abscess
* Pregnancy or lactation
* Allergic reaction to components of 1% clascoterone cream
* Febrile illness within 7 days
* Treatment with another investigational drug within three months

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Lillias Maguire, MD
• Email: lillias.maguire@pennmedicine.upenn.edu
• Phone: 215-662-2078

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sacral ESP Block to Help Pain After Pilonidal Sinus Surgery

  This study tests whether an ultrasound-guided sacral erector spinae plane (ESP) block after pilonidal sinus surgery can reduce pain and opioid use.

  Recruiting Medipol University · Istanbul · NCT07534488

• Wound cleaning during pilonidal surgery: saline vs. hypochlorous acid

  This study tests whether irrigating the surgical wound with hypochlorous acid during pilonidal disease surgery helps wounds heal faster than saline in Stage 3 cases.

  Recruiting Stanford University · Palo Alto, California · NCT07417202

• Chlorhexidine (Irrisept) versus normal saline rinse for flap closure in pilonidal disease

  This will see if rinsing the surgical wound with Irrisept (0.05% chlorhexidine) instead of normal saline reduces infections and other wound problems in adults having fasciocutaneous flap surgery for pilonidal disease.

  Recruiting Nasseri,Yosef MD · Los Angeles, California · NCT07321704

• Laser treatment with two-year follow-up for pilonidal cysts

  This project will see if laser surgery prevents pilonidal sinus recurrence within two years in adults who need the procedure.

  Recruiting at 2 sites Centre Hospitalier Departemental Vendee · Cornebarrieu and 1 other locations · NCT07314632

• Impact of pilonidal cyst recurrence after surgery or laser on quality of life

  This project will see how recurring pilonidal cysts after prior surgery or laser affect quality of life for patients who come back with a recurrence.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lyon · NCT07194161

• Improving wound healing for complex pilonidal sinus disease with a new care pathway

  This study is testing a new care plan for people with complex pilonidal sinus disease to see if it helps them heal faster and get back to their normal activities better than the usual surgery.

  Recruiting Albert Schweitzer Ziekenhuis, Netherlands · Dordrecht · NCT06683274

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.