Comparing nasal and oral breathing during drug-induced and natural sleep
The Impact of Nasal Versus Oral Breathing on Measures of Drug-Induced Sleep Endoscopy
This study is testing whether the way people with obstructive sleep apnea breathe (through their nose or mouth) during drug-induced sleep matches how they breathe during natural sleep.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT06789770 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between the route of breathing (nasal vs oral) and airway collapsibility in patients with obstructive sleep apnea (OSA). Participants will undergo a drug-induced sleep endoscopy (DISE) to determine their breathing route as a percentage of total breaths during different sleep states. Additionally, an in-laboratory polysomnogram will be performed to assess breathing patterns using a specialized cannula. The findings will help clarify whether breathing routes during DISE accurately reflect those during natural sleep.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with at least mild obstructive sleep apnea who have been evaluated at the CPAP Alternatives Clinic.
Not a fit: Patients with a sleep study showing an apnea-hypopnea index (AHI) of less than 5 or significant central/mixed events may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of breathing mechanics in OSA, leading to improved treatment strategies.
How similar studies have performed: While this approach is novel in its specific focus, similar studies have explored the implications of breathing routes in sleep apnea with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Adults (≥ 18yrs) that underwent clinical evaluation at the CPAP Alternatives Clinic at Penn Otorhinolaryngology. * Must have at least mild OSA (AHI\>5) Exclusion Criteria: * • Sleep study with an AHI\<5, \>25% of total events being central or mixed events, or inability to achieve adequate drug-induced sleep. * Upper Respiratory Illness at the time of the DISE.
Where this trial is running
Philadelphia, Pennsylvania
- Hospital at the University of Pennsylvania — Philadelphia, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Julianna Rodin, MD — University of Pennsylvania
- Study coordinator: Everett Seay
- Email: seaye@pennmedicine.upenn.edu
- Phone: 215-662-2777
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.