Integrated single-nucleus multi-omics to map human trigeminal ganglion biology
Official title: Project #2 Integrated single-nucleus multi-omics (ATAC-seq+RNA-seq or chromatin accessibility + RNA-seq) of human TGs
Funded at University of Pennsylvania · NIH-11564964 · Data updated 2026-11-12
This NIH grant aims to create detailed molecular maps of human trigeminal ganglion cells under normal and migraine conditions to help find new ways to treat headaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $459,721 |
| NIH project number | 4U19NS135528-02 |
| Project ID | NIH-11564964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with migraine or related trigeminal pain conditions, and future patients who may benefit from targeted therapies informed by this atlas.
✕Less likely to help
People without migraine or trigeminal pain may not directly benefit from the study results.
What this research studies
Researchers at the University of Pennsylvania plan to use advanced single-nucleus multi-omics methods to study human trigeminal ganglion tissue, focusing on how gene regulation and RNA profiles change in migraine. The project will run through 2023–2028 with dedicated cores and three interrelated projects to build a comprehensive atlas of pain-related cells and genes. By combining chromatin accessibility and RNA data, they hope to uncover molecular targets and pathways involved in migraine biology that could lead to better therapies. Participants would be drawn from brain tissue analyses and related human samples, with findings intended to inform future patient-directed research and treatments.
Why it matters
Potential benefit: Could identify new molecular targets and pathways to develop more effective migraine treatments.
How similar studies have gone: Previous single-cell and multi-omics studies have shown the power of this approach to reveal disease-relevant cell types and gene regulation in human tissues.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Wu, Hao — University of Pennsylvania
- Study coordinator: Wu, Hao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.