Brain activity in movement disorders: basal ganglia, thalamus, and cerebellum

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This protocol records electrical brain activity from the scalp and, when available, from implanted deep brain stimulators in adults with Parkinson's disease, tremor, dystonia, cerebellar ataxia, or other hyperkinetic disorders. Recordings include noninvasive scalp electrodes and device-based sensing from compatible DBS systems, and data are collected alongside clinical measures of movement symptoms. Some participants may have medication adjustments or DBS programming changes as part of the protocol to capture different symptom states. The resulting signals are analyzed to identify neural signatures linked to symptom fluctuations that could inform biomarkers or future therapy adjustments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients 18 years of age and above
* Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
* Parkinson's disease
* Dystonia
* Tremor, including essential tremor
* Cerebellar ataxia
* Other hyperkinetic movement disorders, such as chorea and tics

Exclusion Criteria:

\- Patients with dementia

Where it's running

• Pennsylvania Hospital
  Philadelphia, Pennsylvania, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.