Clinical trial Recruiting at 1 site Early Phase 1 Interventional Ages 18 and up

Evaluating the effects of a nerve block on heart rhythm issues

Official title: Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

Run by University of Pennsylvania · NCT05377216 · Data updated 2026-11-12

This study is testing if a nerve block can help improve heart rhythm problems in people with ventricular tachycardia during a planned heart procedure.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment20 (estimated)
SponsorUniversity of Pennsylvania
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedSeptember 1, 2022
Main results expectedJuly 1, 2027
Study endsJuly 1, 2027
Registry record updatedNovember 21, 2025
Trial IDNCT05377216 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are scheduled for catheter-based ventricular tachycardia ablation.

Probably not a fit

Patients who are pregnant, have contraindications to the stellate ganglion block or ventricular tachycardia ablation, or are experiencing hemodynamic instability may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the electrophysiological and biochemical impacts of stellate ganglion block in patients experiencing ventricular tachycardia. It is a prospective cohort study that aims to understand how this intervention may influence heart rhythm and function. Participants will undergo a planned catheter-based ablation procedure while being monitored for changes in their cardiac condition. The study focuses on gathering data to assess the effectiveness of this neuromodulation technique.

Why it matters

Potential benefit: If successful, this approach could lead to improved management and treatment options for patients with ventricular tachycardia.

How similar studies have gone: While the specific approach of using stellate ganglion block for ventricular tachycardia is novel, similar neuromodulation techniques have shown promise in other cardiac conditions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Planned catheter based VT ablation
* Age at least 18 years

Exclusion Criteria:

* Pregnancy
* Contraindication to SGB or VT ablation
* Hypersensitivity of local anesthetic of amide type
* Hemodynamic instability during the procedure prior to the study protocol

Where it's running

  • Hospital of the University of Pennsylvania
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.