Evaluating the effects of a nerve block on heart rhythm issues
Official title: Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Run by University of Pennsylvania · NCT05377216 · Data updated 2026-11-12
This study is testing if a nerve block can help improve heart rhythm problems in people with ventricular tachycardia during a planned heart procedure.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | September 1, 2022 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT05377216 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are scheduled for catheter-based ventricular tachycardia ablation.
✕Probably not a fit
Patients who are pregnant, have contraindications to the stellate ganglion block or ventricular tachycardia ablation, or are experiencing hemodynamic instability may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the electrophysiological and biochemical impacts of stellate ganglion block in patients experiencing ventricular tachycardia. It is a prospective cohort study that aims to understand how this intervention may influence heart rhythm and function. Participants will undergo a planned catheter-based ablation procedure while being monitored for changes in their cardiac condition. The study focuses on gathering data to assess the effectiveness of this neuromodulation technique.
Why it matters
Potential benefit: If successful, this approach could lead to improved management and treatment options for patients with ventricular tachycardia.
How similar studies have gone: While the specific approach of using stellate ganglion block for ventricular tachycardia is novel, similar neuromodulation techniques have shown promise in other cardiac conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Planned catheter based VT ablation * Age at least 18 years Exclusion Criteria: * Pregnancy * Contraindication to SGB or VT ablation * Hypersensitivity of local anesthetic of amide type * Hemodynamic instability during the procedure prior to the study protocol
Where it's running
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Study coordinator: Timothy Markman, MD
- Email: timothy.markman@pennmedicine.upenn.edu
- Phone: 267-593-0103
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Parasternal EV-ICD System Pivotal Study
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Real-time intracardiac ultrasound to guide ablation of ventricular arrhythmias
It tests whether using ultrasound inside the heart during PVC or VT ablation can reduce X-ray exposure for adults having these procedures.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.