Evaluating the effects of a nerve block on heart rhythm issues
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
EARLY_PHASE1 · University of Pennsylvania · NCT05377216
This study is testing if a nerve block can help improve heart rhythm problems in people with ventricular tachycardia during a planned heart procedure.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pennsylvania (other) |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT05377216 on ClinicalTrials.gov |
What this trial studies
This study investigates the electrophysiological and biochemical impacts of stellate ganglion block in patients experiencing ventricular tachycardia. It is a prospective cohort study that aims to understand how this intervention may influence heart rhythm and function. Participants will undergo a planned catheter-based ablation procedure while being monitored for changes in their cardiac condition. The study focuses on gathering data to assess the effectiveness of this neuromodulation technique.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for catheter-based ventricular tachycardia ablation.
Not a fit: Patients who are pregnant, have contraindications to the stellate ganglion block or ventricular tachycardia ablation, or are experiencing hemodynamic instability may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved management and treatment options for patients with ventricular tachycardia.
How similar studies have performed: While the specific approach of using stellate ganglion block for ventricular tachycardia is novel, similar neuromodulation techniques have shown promise in other cardiac conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Planned catheter based VT ablation * Age at least 18 years Exclusion Criteria: * Pregnancy * Contraindication to SGB or VT ablation * Hypersensitivity of local anesthetic of amide type * Hemodynamic instability during the procedure prior to the study protocol
Where this trial is running
Philadelphia, Pennsylvania
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (RECRUITING)
Study contacts
- Study coordinator: Timothy Markman, MD
- Email: timothy.markman@pennmedicine.upenn.edu
- Phone: 267-593-0103
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ventricular Tachycardia