Data Core supports a national effort to map human pain genes in migraine patients
Official title: Data Core
Funded at University of Pennsylvania · NIH-11564968 · Data updated 2026-11-12
This grant funds a data core to store and analyze genetic and neural data from human trigeminal neurons to better understand migraine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $257,796 |
| NIH project number | 4U19NS135528-02 |
| Project ID | NIH-11564968 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with migraine or those at risk who contribute tissue or data samples or participate in studies related to trigeminal neurons.
✕Less likely to help
Individuals not contributing samples or data or not enrolled in related projects may not directly benefit.
What this research studies
The Penn HPPC will collect and integrate molecular, cellular, epigenetic, and physiological data from human trigeminal neurons at baseline and during migraine. The data core provides advanced statistics, bioinformatics, and computing support to three projects within the center. Researchers will use single-cell and spatial transcriptomics to build a comprehensive map of human pain-related genes and cells.
Why it matters
Potential benefit: If successful, the project could reveal new targets and pathways for migraine treatments.
How similar studies have gone: Preliminary studies in single-cell transcriptomics of human sensory neurons have shown promising paths for understanding pain at the molecular level.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Li, Mingyao — University of Pennsylvania
- Study coordinator: Li, Mingyao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.