Human Tissue Core for Pain Research at Penn HPPC
Official title: Human Tissue Core
Funded at University of Pennsylvania · NIH-11564966 · Data updated 2026-11-12
A dedicated center at the University of Pennsylvania will collect, store, and share human trigeminal tissue to study migraine biology and pain signaling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $113,790 |
| NIH project number | 4U19NS135528-02 |
| Project ID | NIH-11564966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with migraine or related trigeminal system pain who may contribute tissue samples or participate in tissue-based research
✕Less likely to help
Participants not contributing tissue or whose condition is not part of the trigeminal pain studies may not directly benefit
What this research studies
This project centers on creating a Penn Human Precision Pain Center that collects and processes human tissues related to migraine. Researchers will carefully procure trigeminal ganglion tissues, preserve them, and share them with multiple studies to uncover how human pain signals are wired at baseline and during migraine. The effort builds on prior deep RNA sequencing work and connects with NIH networks to standardize tissue handling and data sharing. The work aims to translate molecular and cellular insights into better, more targeted treatments for migraine sufferers.
Why it matters
Potential benefit: If successful, the work could lead to more precise targets for migraine therapies and faster development of effective treatments.
How similar studies have gone: Similar tissue-based pain studies have advanced understanding, but this center expands access to high-quality human trigeminal tissue and standardized protocols
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Luo, Wenqin — University of Pennsylvania
- Study coordinator: Luo, Wenqin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.