Development and evaluation of advanced photon-counting CT technology
Official title: Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
Run by University of Pennsylvania · NCT06691659 · Data updated 2026-11-12
This study is testing a new type of CT scan that uses less radiation and provides clearer images to see if it can improve diagnosis for patients needing routine scans.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | November 19, 2024 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT06691659 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 89 who are scheduled for routine CT imaging and can provide informed consent.
✕Probably not a fit
Patients who are pregnant, have a known contrast allergy, or possess medical conditions that may compromise their safety or participation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on the development and clinical evaluation of a next-generation photon-counting computed tomography (PCCT) prototype. The study aims to assess the diagnostic benefits of PCCT, which offers reduced radiation doses, high spatial resolution, and spectral imaging capabilities. A total of 250 patients scheduled for routine CT scans will be recruited, with analyses conducted by trained radiologists interpreting both conventional and advanced imaging data. The goal is to gather preliminary data that could inform future research and clinical applications.
Why it matters
Potential benefit: If successful, this technology could significantly enhance diagnostic performance while minimizing radiation exposure for patients.
How similar studies have gone: Other studies have shown promise with advanced imaging technologies, but this specific approach using photon-counting CT is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 89. * Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. * Not pregnant (based on attestation) Exclusion Criteria: * Pregnant women will not be included. All females of childbearing potential must attest that they are not pregnant before CT imaging. * Participants with a known contrast allergy. * Any current medical condition, illness, or disorder, as assessed by medical record review and/or self-reported, that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study.
Where it's running
-
University of Pennsylvania - Center for Advanced Computed Tomography Imaging Services (CACTIS)
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Peter B Noel, PhD — UPENN Radiology
- Study coordinator: Erin Schubert
- Email: erin.schubert@pennmedicine.upenn.edu
- Phone: 215-573-6569
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.