Using Transcranial Magnetic Stimulation and Language Therapy to Improve Mild Aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of combining Transcranial Magnetic Stimulation (TMS) with Speech-Language Therapy (SLT) to treat mild aphasia in individuals who have experienced a stroke. Participants will undergo a screening process, MRI, and then receive 10 consecutive sessions of TMS and SLT. The study aims to assess improvements in conversational speech and comprehension while also identifying specific characteristics that may predict treatment success. A comparison will be made between real TMS and sham TMS to evaluate the treatment's efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Left Hemisphere stroke
* Stroke occurred more than 6 months ago
* Mild Aphasia (WAB AQ score \> 85)
* Proficient in English

Exclusion Criteria:

* Ongoing substance or alcohol abuse
* Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
* Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
* Pacemaker or cardiac defibrillator
* Diagnosis of tinnitus
* Epilepsy, or seizure in the past 6 months

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: H. Branch Coslett, MD — University of Pennsylvania
• Study coordinator: Harris Drachman, MS
• Email: harris.drachman@pennmedicine.upenn.edu
• Phone: 215-964-2502

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• tDCS in Rehab for Stroke-Related Aphasia: A Practical Implementation

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.