Identifying blood biomarkers for obstructive sleep apnea using microRNAs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop and validate blood biomarkers specific to obstructive sleep apnea (OSA) by analyzing microRNAs. The research will compare microRNA profiles between individuals with moderate to severe OSA and healthy controls matched for age, sex, and body mass index. The study will utilize sequencing techniques and quantitative PCR to assess microRNA expression, which may help improve case identification, monitor therapy efficacy, and predict blood pressure responses to treatment. By establishing these biomarkers, the study seeks to enhance the management of OSA patients.

Why it matters

Who can join: the full rules

Inclusion Criteria for Cases:

* age 18-75 years
* moderate-severe OSA (defined as AHI ≥15 events/hour)
* willing to accept PAP therapy

Inclusion Criteria for Controls:

* age 18-75 years
* no OSA (defined as AHI \<5 events/hour)

Exclusion Criteria for Cases:

* current use of PAP or other OSA treatments
* home oxygen therapy
* recent changes (within 3 months) to BP medications among those who are on these medications
* presence of Cheyne-Stokes Respiration (CSR) in sleep study
* predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events)
* pregnancy
* clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
* organ transplantation
* self-reported sleep duration less than 5 hours per night on weeknights (work nights)
* current night shift work

Exclusion Criteria for Controls:

* home oxygen therapy
* pregnancy
* clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
* organ transplantation
* self-reported sleep duration less than 5 hours per night on weeknights (work nights)
* current night shift work

Where it's running

• The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600
  Columbus, Ohio, United States Recruiting
• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting
• University of Iceland
  Reykjavik, Iceland Recruiting

Study contacts

• Principal investigator: Allan I Pack, MBChB, PhD — University of Pennsylvania
• Study coordinator: Colleen M Walsh, MS
• Email: walshco@pennmedicine.upenn.edu
• Phone: 215-614-0047

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.