Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational project that creates and expands a biobank of blood, DNA/RNA, family history, and related demographic data from individuals with neurodegenerative conditions or their at‑risk relatives. The goal is to support research into the molecular and genetic factors that contribute to diseases like FTD, ALS, PPA, and related conditions. Enrollment is open to people with a diagnosed neurodegenerative disease, their family members, and some individuals without known neurological disease. The study collaborates with the University of Pennsylvania and national aging/neurological research institutes to maintain and utilize the repository for future investigations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment
2. Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk.
3. People with no known neurological disease who will provide control data.

Exclusion Criteria:

1. Anyone who is under the age of 18.
2. Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Corey McMillan, PhD — University of Pennsylvania
• Study coordinator: Cara Joyce, MPH
• Email: cara.joyce@pennmedicine.upenn.edu
• Phone: 267-271-0740

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.