NAD+ Levels in Healthy Adults Before and After Taking NR
Official title: Validation of NAD+ Measurements for Human Clinical Studies: Multi-method Inter-laboratory Standardization
Run by University of Pennsylvania · NCT07416786 · Data updated 2026-11-12
This study tests whether taking an over-the-counter nicotinamide riboside (NR) for 30 days changes NAD+ levels in blood and tissue of healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 110 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2028 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT07416786 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18-35 or 70 and older, regardless of sex, who can undergo MRI and meet contraception and health criteria.
✕Probably not a fit
Individuals with diabetes requiring insulin, significant organ disease, MRI contraindications, or those taking certain medications or supplements may not experience benefit from NR in this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an open-label, nonrandomized study that will measure NAD+ and related metabolites in blood, urine, and tissue using magnetic resonance spectroscopy. The study enrolls 48 participants divided into two age groups: 18-35 and 70+, with both men and women included. Participants will take 1000 mcg of NR daily for 30 days, with baseline and follow-up measurements on days 29 and 30. Assessors analyzing the outcomes will be blinded to participant status to reduce bias. The primary goal is to correlate in vivo NAD+ measurements with blood and tissue metabolite levels in response to NR supplementation.
Why it matters
Potential benefit: If successful, this could clarify how NR affects NAD+ levels in healthy adults and inform future dosing or biomarker strategies.
How similar studies have gone: Prior research has explored NR effects on NAD+ in various settings, but this study adds direct in vivo tissue measurements in a healthy population.
Who can join: the full rules
Show full inclusion / exclusion criteria
* Male or female age18-35 years or 70 years or older, healthy * if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation). * No known sensitivity to NR * No use of niacin, blood thinners or chemotherapy agents * HbA1c below 8.5% and not diabetec requiring insulin. * Not using/taking corticosteroids * No laboratory abnormalities indicating significant anemia, bleeding risk, kidney disease, or liver disease * No contraindication to MRI * Not Pregnant, lactating, or planning to become pregnant during participation * Not taking multivitamins or any over-the-counter supplements except calcium and vitamin D (any other supplements - discontinued 2 weeks prior to study participation). * not taking/ undergoing another investigational drug or other intervention within the past 30 days.
Where it's running
-
Penn Medicine
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Ravinder Reddy, Ph.D. — University of Pennsylvania
- Study coordinator: Damodar Reddy
- Email: cdamodar@pennmedicine.upenn.edu
- Phone: 215-898-9357
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.