Changes in brain connectivity after theta burst stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of transcranial magnetic stimulation (TMS) on brain connectivity by developing a comprehensive model that predicts changes in resting state functional connectivity following TMS. The research will involve healthy volunteers receiving either intermittent or continuous theta burst stimulation, with the aim of understanding how the current density at the cortex influences these connectivity changes. By measuring brain connectivity before and after TMS, the study seeks to validate a whole-brain model that can generalize across various conditions and predict psychiatric symptom changes. This work addresses a critical gap in the understanding of TMS effects on brain network architecture.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Able to give their consent
* Right-handed

Exclusion Criteria

* Non-english speaking
* Any significant medical problems
* Current or past Axis I psychiatric disorder(s),
* Active or history of active suicidal ideation
* Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
* Medications that act on the central nervous system
* History of seizure
* History of epilepsy or other neurological problems
* Increased risk of seizure for any reason
* Pregnancy
* Any medical condition that increases risk for fMRI or TMS
* Any metal in their body which would make having an MRI scan unsafe
* Any sort of medical implants
* Claustrophobia

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Nicholas L Balderston — University of Pennsylvania
• Study coordinator: Nicholas L Balderston
• Email: nicholas.balderston@pennmedicine.upenn.edu
• Phone: 2157463058

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.