Chin contour enhancement with hyaluronic acid filler
Official title: 3-Dimensional Volumetric Analysis of a Hyaluronic Filler Injection for Chin Profile Enhancement
Run by University of Pennsylvania · NCT07777926 · Data updated 2026-11-12
This study tests whether injecting hyaluronic acid filler into the lower face can restore chin projection and symmetry in adults who want a more defined chin.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 22 Years to 55 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | September 30, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07777926 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 22-55 seeking improved chin profile and contour who have not had a filler for facial contouring in the past year and can provide informed consent.
✕Probably not a fit
Individuals unlikely to benefit include those with prior recent facial filler or cosmetic surgery contraindications or conditions affecting filler longevity.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, phase 4 study measures how much volume remains in the lower face after hyaluronic acid filler injections over 90 days. Participants receive FDA-approved filler dosages targeting chin contour and regression, with 3D facial imaging before and after to quantify changes. Follow-up visits at 2 weeks, 1 month, and 3 months include re-imaging and patient-reported outcome data collected via FACE-Q to capture satisfaction and perceived changes. The study will analyze volumetric changes and adverse events to understand durability and safety in this indication.
Why it matters
Potential benefit: If successful, participants may experience improved chin projection and facial symmetry with durable results over several months.
How similar studies have gone: Previous studies of facial fillers for chin contouring have shown meaningful, though time-limited, improvements in volume and satisfaction.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 22-55 * Patients interested in chin profile enhancement. * Participants must sign the informed consent form. Exclusion Criteria: * Prior filler for facial contouring * Filler injection within the past 12 months or during duration of study * Prior facial cosmetic surgery (i.e.. facelift) * Prior facial trauma (i.e.. orbital fracture) * Pregnant or breastfeeding at the time of injection (initial visit) * Planned dental work within next 2 weeks * The following contraindications: patients with known hypersensitivity or severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies, gram-positive bacterial protein allergies, lidocaine allergies or other local anesthetics of the amide type * Patients with known bleeding disorders
Where it's running
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Penn Medicine
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Study coordinator: Aamirah McCutchen
- Email: aamirah.mccutchen@pennmedicine.upenn.edu
- Phone: 215-360-0652
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.