Managing placenta accreta spectrum while preserving the uterus

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on the conservative management of placenta accreta spectrum disorders, which pose significant risks to maternal health. Instead of the common approach of cesarean-hysterectomy, this pilot study offers selected participants the option to leave the placenta in the uterus after delivery. The study will involve 15 participants who desire uterine preservation and will be monitored during their postpartum stay and through outpatient follow-up until the uterus is empty. This approach aims to provide a safer alternative for women facing this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Provision of signed and dated informed consent form.
2. Stated willingness to comply with all study procedures and availability for the duration of the study.
3. A person with a uterus, age 18 or older
4. Currently pregnant with an intrauterine gestation or postpartum
5. Suspected of having PAS based on history, clinical findings, and/or imaging
6. Patients for whom the usual management would be peripartum hysterectomy.
7. Patient desires uterine preservation or declines hysterectomy
8. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration.

Exclusion Criteria:

• Have a low antenatal suspicion for PAS based on imaging.

Where it's running

• Hospital of the University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Beth Pineles, MD PhD — University of Pennsylvania
• Study coordinator: Beth Pineles, MD Phd
• Email: beth.pineles@pennmedicine.upenn.edu
• Phone: 267-226-7933

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Vision Transformer–based ultrasound AI to detect placenta accreta spectrum

  A AI tool uses ultrasound video inputs to help see if the placenta is abnormally attached during pregnancy in women at risk.

  Recruiting The Third Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT07643090

• Three conservative surgeries for placenta accreta spectrum: a comparison

  Researchers compare three uterus-preserving surgical options to see which works best for placenta accreta spectrum.

  Recruiting Assiut University · Asyut · NCT07520201

• Planned cesarean at 37 weeks versus 36 weeks for pregnancies with placenta previa and accreta

  We will test whether scheduling cesarean delivery at 37 weeks instead of 36 weeks helps newborns without increasing maternal bleeding in pregnant women with placenta previa and accreta.

  Recruiting The Third Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong and 5 other locations · NCT07025954

• High versus low segmental hysterotomy and uterine scar defects after a first cesarean

  We will test whether high or low segmental hysterotomy, with or without cross-suturing, leads to fewer uterine scar defects in people having their first cesarean.

  Recruiting Fundacion Clinica Valle del Lili · Cali, Valle del Cauca Department · NCT06620432

• Outcomes of Uterine Conservation in Placenta Accreta Spectrum

  This study looks at how well uterine conservation procedures work for women with placenta accreta spectrum by tracking their recovery, blood loss, and menstrual return after the surgery.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT04866888

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.